PMID- 11601324
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20061115
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 112
IP  - 6
DP  - 1999 Jun
TI  - Significant reduction of T-cell chemotaxis to MCP-1 in patients with primary and 
      metastatic melanoma.
PG  - 493-6
AB  - OBJECTIVE: To address whether circulating T-cells from the patients with primary 
      and metastatic malignant melanoma show altered chemotaxis to monocyte-chemotactic 
      protein 1 (MCP-1) and its relation to tumor infiltrating lymphocyte (TIL) and 
      metastasis. METHODS: Chemotactic response of T-cells towards MCP-1 and 
      immuno-histochemistry study of TIL and tumor-associated-macrophages (TAM) were 
      investigated in patients with primary and metastatic melanoma compared to 
      patients with basal cell carcinoma and healthy persons. RESULTS: T-cells from 
      patients with primary and metastatic melanoma showed a significantly decreased 
      chemotactic migration towards MCP-1 and T-cells from patients with basal cell 
      carcinoma showed normal chemotactic response. Immuno-histochemistry study showed 
      that there was no correlation between the number of TIL and the decreased 
      chemotaxis of circulating T-cells to MCP-1 in patients with primary melanoma. 
      CONCLUSIONS: Circulating T-cells from patients with primary and metastatic 
      melanoma showed a MCP-1-specific decrease in chemotactic migration. This may be 
      due to abnormal expression or modulation of MCP-1-receptor expression on these 
      cells.
FAU - Zheng, M
AU  - Zheng M
AD  - Department of Dermatology, Second Affiliated Hospital of Zhejiang Medical 
      University, Hangzhou 310009, China.
FAU - Sun, G
AU  - Sun G
FAU - Cai, S
AU  - Cai S
FAU - Mueller, R
AU  - Mueller R
FAU - Mrowietz, U
AU  - Mrowietz U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemokine CCL2/*immunology
MH  - *Chemotaxis, Leukocyte
MH  - Female
MH  - Humans
MH  - Lymphocyte Subsets/immunology
MH  - Lymphocytes, Tumor-Infiltrating/immunology
MH  - Macrophages/immunology
MH  - Male
MH  - Melanoma/*immunology/secondary
MH  - Middle Aged
MH  - Skin Neoplasms/immunology
MH  - T-Lymphocytes/*immunology
EDAT- 2001/10/17 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/17 10:00
PHST- 2001/10/17 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/17 10:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 1999 Jun;112(6):493-6.