PMID- 11603299
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20031114
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 21
IP  - 12
DP  - 2000 Dec
TI  - Protective effect of gypenosides on DNA and RNA of rat neurons in cerebral 
      ischemia-reperfusion injury.
PG  - 1193-6
AB  - AIM: To observe the protective effect of gypenosides (GP) on the neurons of 
      hippocampus, cerebral cortex, corpus striatum, and dentate gyrus in cerebral 
      ischemia-reperfusion injury of rats. METHODS: Modified 4-vessel occlusion (4-VO) 
      method was used to establish the model of acute global ischemia. The acridine 
      orange (AO) staining method was used to observe the DNA and RNA contents of 
      cerebral ischemia-reperfusion injury model in the areas. RESULTS: The fluorescent 
      intensity (reflecting DNA and RNA contents) of the DNA and RNA in the areas of 
      cerebral ischemia-reperfusion injury was markedly abated compared with the normal 
      control group. In the group of ig GP (100 mg/kg) it was enhanced compared with 
      the model group and was the same as the normal control group. CONCLUSION: The 
      injury of the DNA and RNA in the areas of ischemia-reperfusion model was 
      decreased by GP.
FAU - Qi, G
AU  - Qi G
AD  - Department of Pharmacology, Medical College of CPAPF, Tianjin 300162, China.
FAU - Zhang, L
AU  - Zhang L
FAU - Xie, W L
AU  - Xie WL
FAU - Chen, X Y
AU  - Chen XY
FAU - Li, J S
AU  - Li JS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Saponins)
RN  - 63231-63-0 (RNA)
RN  - 80321-63-7 (gypenoside IX)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain Ischemia/complications
MH  - Cerebral Cortex/metabolism
MH  - Cucurbitaceae/*chemistry
MH  - DNA/*metabolism
MH  - Drugs, Chinese Herbal/chemistry
MH  - Male
MH  - Neurons/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Plants, Medicinal/chemistry
MH  - RNA/*metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/etiology/*metabolism
MH  - Saponins/isolation & purification/*pharmacology
EDAT- 2001/10/18 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/18 10:00
PHST- 2001/10/18 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/18 10:00 [entrez]
PST - ppublish
SO  - Acta Pharmacol Sin. 2000 Dec;21(12):1193-6.