PMID- 11604250
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 56
IP  - 1
DP  - 2001 Sep 1
TI  - Prostaglandins may participate in opioidergic and cholinergic control of the 
      diurnal changes of tuberoinfundibular dopaminergic neuronal activity and serum 
      prolactin level in ovariectomized, estrogen-treated rats.
PG  - 61-5
AB  - The roles of prostaglandins (PGs) involved in opioidergic, cholinergic, and 
      serotonergic regulation of the diurnal changes of tuberoinfundibular dopaminergic 
      (TIDA) neuronal activities were investigated in ovariectomized, estrogen-treated 
      rats. Treatment with naloxone [10 mg/kg, intraperitoneal (i.p.)], atropine (5 
      mg/kg, i.p.), or ketanserin (10 mg/kg, i.p.) at either 1200 or 1400 h prevented 
      the afternoon decrease of TIDA neuronal activity and the prolactin (PRL) surge. 
      Intracerebroventricular (i.c.v.) injection of PGE(1) (5 microg/3 microl/rat) at 
      1500 h significantly reversed the effects of naloxone and atropine, but not that 
      of ketanserin. In ovariectomized, estrogen-primed rats pretreated with 
      indomethacin, i.c.v. injection of either nicotine (10 ng/rat) or fentanyl (10 
      ng/rat) failed to suppress the TIDA neuronal activity and to stimulate the PRL 
      secretion. These data suggest that PG may be involved in opioidergic and 
      cholinergic control of the diurnal changes of TIDA neuronal activity and the PRL 
      secretion in ovariectomized (OVX) + E(2) rats.
FAU - Chu, Y C
AU  - Chu YC
AD  - Department of Clinical Medicine, School of Medicine, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Tsou, M Y
AU  - Tsou MY
FAU - Pan, J T
AU  - Pan JT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Estrogens)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Opioid Peptides)
RN  - 0 (Prostaglandins)
RN  - 333DO1RDJY (Serotonin)
RN  - 36B82AMQ7N (Naloxone)
RN  - 9002-62-4 (Prolactin)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - N9YNS0M02X (Acetylcholine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Acetylcholine/*metabolism
MH  - Analgesics, Opioid/pharmacology
MH  - Animals
MH  - Circadian Rhythm/drug effects/*physiology
MH  - Dopamine/*metabolism
MH  - Estrogens/metabolism/pharmacology
MH  - Female
MH  - Hypothalamo-Hypophyseal System/drug effects/metabolism
MH  - Ketanserin/pharmacology
MH  - Median Eminence/drug effects/*metabolism
MH  - Muscarinic Antagonists/pharmacology
MH  - Naloxone/pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Neurons/drug effects/*metabolism
MH  - Opioid Peptides/*metabolism
MH  - Ovariectomy
MH  - Prolactin/*blood/metabolism
MH  - Prostaglandins/*metabolism/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
EDAT- 2001/10/18 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/18 10:00
PHST- 2001/10/18 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/18 10:00 [entrez]
AID - S0361-9230(01)00605-0 [pii]
AID - 10.1016/s0361-9230(01)00605-0 [doi]
PST - ppublish
SO  - Brain Res Bull. 2001 Sep 1;56(1):61-5. doi: 10.1016/s0361-9230(01)00605-0.