PMID- 11604266
OWN - NLM
STAT- MEDLINE
DCOM- 20011231
LR  - 20190910
IS  - 0378-5173 (Print)
IS  - 0378-5173 (Linking)
VI  - 229
IP  - 1-2
DP  - 2001 Oct 23
TI  - Comparative study of the leachability of di(2-ethylhexyl) phthalate and 
      tri(2-ethylhexyl) trimellitate from haemodialysis tubing.
PG  - 139-46
AB  - The leachability of both Di(2-ethylhexyl) phthalate (DEHP) and Tri(2-ethylhexyl) 
      trimellitate (TEHTM) or Trioctyl trimellitate (TOTM) from haemodialysis tubing 
      was investigated in 20 patients with chronic renal failure undergoing maintenance 
      haemodialysis. The blood tubing made of common polyvinyl chloride (PVC) 
      plasticized with DEHP (group 1 patients) were replaced with tubing plasticized 
      with TOTM-DEHP (group 2 patients). The patient blood obtained from the inlet and 
      the outlet of the dialyzer was analyzed during a 4 h-dialysis session. Thus, the 
      circulating concentrations of both DEHP and TOTM resulting from the release from 
      dialyzer tubes were estimated using High-performance Liquid chromatograph (HPLC). 
      With the common PVC-DEHP blood tubing, a DEHP quantity of 122.95+/-33.94 mg was 
      extracted from tubing during a single dialysis session (ranging from 55 to 166.21 
      mg). During the same period, the total amounts of DEHP retained by the patients 
      were 27.30+/-9.22 mg (ranging from 12.50 to 42.72 mg). As for blood tubing 
      plasticized with TOTM-DEHP, 41.80+/-4.47 mg of DEHP and 75.11+/-25.72 mg of TOTM 
      were extracted. During the same period, the amounts of DEHP and TOTM retained by 
      the patients were 3.42+/-1.37 mg and 4.87+/-2.60 mg, respectively. The extraction 
      rate both plasticizers was correlated with serum lipid content 
      (cholesterol+triglyceride) (r(2)=0.75 for DEHP and r(2)=0.64 for TOTM). In the 
      present investigation, less TOTM and DEHP were apparently released from 
      haemodialysis tubing plasticized with TOTM-DEHP than DEHP released from 
      haemodialysis tubing plasticized with DEHP only. TOTM seems to be a superior 
      alternative to DEHP for use in medical devices because of its potential lower 
      leachability. To recommend it as an alternative plasticizer, its possible 
      toxicity towards human body should be investigated before it can be used 
      routinely. However, patients undergoing haemodialysis using tubing plasticized 
      with DEHP only are regularly exposed to non negligible amounts of DEHP. In view 
      of several biological effects previously reported, it is time to reconsider the 
      use of DEHP only as a plasticizer.
FAU - Kambia, K
AU  - Kambia K
AD  - Laboratoire de Pharmacologie, Pharmacocinetique et Pharmacie Clinique, Faculte 
      des Sciences Pharmaceutiques et Biologiques, 3 rue du Professeur Laguesse, BP 83, 
      59006 Cedex, Lille, France.
FAU - Dine, T
AU  - Dine T
FAU - Azar, R
AU  - Azar R
FAU - Gressier, B
AU  - Gressier B
FAU - Luyckx, M
AU  - Luyckx M
FAU - Brunet, C
AU  - Brunet C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Benzoates)
RN  - 0 (Plasticizers)
RN  - 0 (Plastics)
RN  - 0 (Triglycerides)
RN  - 3319-31-1 (tri-(2-ethylhexyl)trimellitate)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Benzoates/*chemistry
MH  - Cholesterol/blood
MH  - Chromatography, High Pressure Liquid
MH  - Diethylhexyl Phthalate/*chemistry
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plasticizers
MH  - Plastics
MH  - Renal Dialysis/*instrumentation
MH  - Spectrophotometry, Ultraviolet
MH  - Triglycerides/blood
EDAT- 2001/10/18 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/18 10:00
PHST- 2001/10/18 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/18 10:00 [entrez]
AID - S0378517301008407 [pii]
AID - 10.1016/s0378-5173(01)00840-7 [doi]
PST - ppublish
SO  - Int J Pharm. 2001 Oct 23;229(1-2):139-46. doi: 10.1016/s0378-5173(01)00840-7.