PMID- 11604364
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20091111
IS  - 0007-4551 (Print)
IS  - 0007-4551 (Linking)
VI  - 88
IP  - 9
DP  - 2001 Sep
TI  - [Allogeneic hematopoietic cell transplantation in solid tumors].
PG  - 900-7
AB  - Allogeneic bone marrow transplantation is being used to treat hematologic 
      malignancies after induction. The efficacy of this procedure is due to both 
      myeloablative conditioning and graft versus leukemia (GvL). However, the 
      disadvantages of allogenic transplantation include graft versus host disease 
      (GvH), the susceptibility of patients to opportunistic infections, and relapse 
      from the original tumor. Since 1995 is used conditioning regimen which are deeply 
      immunosuppressive and non myeloablative. The therapeutic toxicity related to 
      myeloablation and drug side effects should be reduced. Lately, allogeneic 
      transplantation has been developed to treat solid tumors, with the expectation 
      that graft versus tumor (GvT), like GvL, will have a significant anti-tumoral 
      effect. According to the literature, the feasibility of this procedure seems 
      demonstrated. The fist available results in renal carcinomas are encouraging. 
      However, the efficacy of this procedure remains uncertain for other potential 
      indications. After presenting the published results, we will discussed the actual 
      difficulties and the future potential developments.
FAU - Bay, J O
AU  - Bay JO
AD  - Unite de transplantation medullaire, Centre regional de lutte contre le cancer 
      Jean-Perrin, BP 392, 63011 Clermont-Ferrand Cedex 01. 
      olivier.bay@cjp.u-clermont1.fr
FAU - Choufi, B
AU  - Choufi B
FAU - Tournilhac, O
AU  - Tournilhac O
FAU - Faucher, C
AU  - Faucher C
FAU - Blaise, D
AU  - Blaise D
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Greffe de cellules souches hematopoietiques allogeniques dans les tumeurs 
      solides.
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
SB  - IM
MH  - Graft vs Host Disease/immunology
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Leukemia/therapy
MH  - Transplantation Conditioning/methods
MH  - Transplantation Immunology
MH  - Transplantation, Homologous
RF  - 66
EDAT- 2001/10/18 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/10/18 10:00
PHST- 2001/10/18 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/10/18 10:00 [entrez]
PST - ppublish
SO  - Bull Cancer. 2001 Sep;88(9):900-7.