PMID- 11606652
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 21
IP  - 21
DP  - 2001 Nov 1
TI  - Cutaneous vasoconstriction contributes to hyperthermia induced by 
      3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits.
PG  - 8648-54
AB  - 3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") increases body temperature. 
      This process could be associated with increased cutaneous blood flow, as normally 
      occurs with exercise-induced hyperthermia. Alternatively, an MDMA-induced fall in 
      cutaneous blood flow could contribute to the hyperthermia by diminishing normal 
      heat transfer from the body to the environment. We investigated these 
      possibilities by administering MDMA (1.5-6 mg/kg, i.v.) to conscious freely 
      moving rabbits, determining effects on body temperature, cutaneous blood flow 
      (measured by a Doppler ultrasonic probe that was chronically implanted around the 
      ear pinna artery), and other cardiovascular parameters. MDMA caused a 
      dose-dependent increase in body temperature (from 38.3 +/- 0.3 to 41.2 +/- 0.4 
      degrees C after 6 mg/kg; p < 0.01; n = 5), preceded and accompanied by a 
      dose-dependent cutaneous vasoconstriction (from 29 +/- 6 to 5 +/- 1 cm/sec after 
      6 mg/kg; p < 0.01; n = 5). MDMA (3 mg/kg) did not change blood flow to the 
      mesenteric vascular bed. Prior unilateral cervical sympathectomy reduced the 
      increase in body temperature elicited by MDMA (6 mg/kg) from 2.0 +/- 0.2 to 1.3 
      +/- 0.2 degrees C (p < 0.01; n = 5). On the denervated side, ear pinna blood flow 
      after MDMA injection was 13 +/- 3 cm/sec, compared with 3 +/- 1 cm/sec on the 
      sympathetically intact side (p < 0.05; n = 5). Thus, sympathetically mediated 
      cutaneous vasoconstriction is one mechanism whereby MDMA causes hyperthermia. 
      Reversal of cutaneous vasoconstriction by appropriate pharmacological means could 
      be of therapeutic benefit in humans suffering from life-threatening hyperthermia 
      induced by MDMA.
FAU - Pedersen, N P
AU  - Pedersen NP
AD  - Departments of Medicine and Physiology, Centre for Neuroscience, Flinders 
      University, Bedford Park 5042, South Australia, Australia.
FAU - Blessing, W W
AU  - Blessing WW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Blood Flow Velocity/drug effects
MH  - Blood Pressure/drug effects
MH  - Body Temperature/drug effects
MH  - Cold Temperature
MH  - Dose-Response Relationship, Drug
MH  - Fever/*chemically induced
MH  - Heart Rate/drug effects
MH  - Hot Temperature
MH  - Linear Models
MH  - Mesenteric Artery, Superior/drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rabbits
MH  - Reproducibility of Results
MH  - Skin/blood supply/*drug effects
MH  - Skin Physiological Phenomena/*drug effects
MH  - Sympathectomy
MH  - Vasoconstriction/*drug effects
PMC - PMC6762811
EDAT- 2001/10/19 10:00
MHDA- 2002/01/05 10:01
PMCR- 2002/05/01
CRDT- 2001/10/19 10:00
PHST- 2001/10/19 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/19 10:00 [entrez]
PHST- 2002/05/01 00:00 [pmc-release]
AID - 21/21/8648 [pii]
AID - 5754 [pii]
AID - 10.1523/JNEUROSCI.21-21-08648.2001 [doi]
PST - ppublish
SO  - J Neurosci. 2001 Nov 1;21(21):8648-54. doi: 10.1523/JNEUROSCI.21-21-08648.2001.