PMID- 1164095
OWN - NLM
STAT- MEDLINE
DCOM- 19751122
LR  - 20131121
IS  - 0003-9780 (Print)
IS  - 0003-9780 (Linking)
VI  - 215
IP  - 2
DP  - 1975 Jun
TI  - Absorption, distribution and excretion of trifluoperazine in rats.
PG  - 318-35
AB  - In rats receiving a low oral dose (0.35 mg/kg p.o.) of trifluoperazine (TFP), a 
      potent neuroleptic phenothiazine, the parent drug distribution was separate from 
      that of its metabolite trifluoperazine sulfoxide (TFP-SO). This was not seen 
      after intraperitoneal administration (i.p.) of the same or high dose (5mg/kg). 
      TFP-SO was not detected in the brain, wheras TFP was significantly associated 
      with microsomes when its brain level was highest. Absorption, distribution, 
      metabolism, and dose dependent excretion procedded rapidly with 97% of a dose 
      recovered 24 hr after p.o. treatment, only 6% in the urine and the remainder in 
      feces with 87% of this metabolized to compounds other than TFP-SO. TFP and its 
      metabolites arrived in feces via two pathways, largely the bile plus another 
      route. The excretion pattern was unchanges with other drugs or after treatment 
      for 3 wk, although excretion differed on the first day after i.p. and p.o. 
      administration.
FAU - West, N R
AU  - West NR
FAU - Vogel, W H
AU  - Vogel WH
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Belgium
TA  - Arch Int Pharmacodyn Ther
JT  - Archives internationales de pharmacodynamie et de therapie
JID - 0405353
RN  - 0 (Sulfoxides)
RN  - 214IZI85K3 (Trifluoperazine)
SB  - IM
MH  - Animals
MH  - Bile/metabolism
MH  - Brain/metabolism/ultrastructure
MH  - Feces/analysis
MH  - Intestinal Absorption
MH  - Liver/metabolism
MH  - Lung/metabolism
MH  - Male
MH  - Rats
MH  - Sulfoxides/metabolism
MH  - Time Factors
MH  - Trifluoperazine/*metabolism
EDAT- 1975/06/01 00:00
MHDA- 1975/06/01 00:01
CRDT- 1975/06/01 00:00
PHST- 1975/06/01 00:00 [pubmed]
PHST- 1975/06/01 00:01 [medline]
PHST- 1975/06/01 00:00 [entrez]
PST - ppublish
SO  - Arch Int Pharmacodyn Ther. 1975 Jun;215(2):318-35.