PMID- 11640969
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20190826
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 124
IP  - 2
DP  - 2001 Oct 15
TI  - Analysis of the effects of CPA and L-histidine on goldfish tested on a 
      conditioned place preference model.
PG  - 161-5
AB  - The aim of this study was to investigate whether the histamine H(1)- receptor 
      blocker chlorpheniramine (CPA) and the histaminergic precursor L-histidine have 
      reinforcing effects in goldfish (Carassius auratus). We used a place-preference 
      procedure in a four-compartment aquarium in which, on the first day, the animals 
      were placed for 30 min for habituation. On the second day, the time spent in each 
      chamber was recorded for 10 min in order to determine which was preferred. After 
      24 h a non-transparent acrylic division was placed in the aquarium to make four 
      identical compartments. The fish were injected intraperotoneally (i.p.) with 
      L-histidine in three doses: 100, 250, and 500 mg/kg of body-weight (n=20) and 
      with vehicle control (n=20). After 30 min the animals were placed in the 
      intermediate preference chamber for another 30 min. The CPA was injected i.p in 
      four doses; 0.4, 1.0, 4.0 or 8.0 mg/kg (n=16) or vehicle (n=16) and after 5 min 
      the animals were placed in the intermediate preference chamber for another 30 
      min. On the fourth day the procedure of the second day was repeated. The results 
      indicate that the group treated with 500 mg/kg L-histidine spent significantly 
      more time in the paired compartment when compared with the time spent before 
      treatment (Wilcoxon Signed Rank Test, P=0.0172). The same behavior was not 
      observed in other treatment groups (P>0.05). The results indicate a reinforcing 
      effect of L-histidine in this place preference model with goldfish.
FAU - Coelho, J L
AU  - Coelho JL
AD  - Laboratory of Neuroscience, Center for Biological and Health Sciences, 
      Universidade Federal de Sao Carlos, Via Washington Luis, Km 235, 13565-905. Sao 
      Carlos SP, Brazil.
FAU - Medalha, C C
AU  - Medalha CC
FAU - Mattioli, R
AU  - Mattioli R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Histamine H1 Antagonists)
RN  - 3U6IO1965U (Chlorpheniramine)
RN  - 4QD397987E (Histidine)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Chlorpheniramine/*pharmacology
MH  - Choice Behavior/drug effects
MH  - Conditioning, Classical/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Goldfish
MH  - Histamine H1 Antagonists/*pharmacology
MH  - Histidine/*pharmacology
MH  - Injections, Intraperitoneal
MH  - *Motivation
MH  - Orientation/*drug effects
EDAT- 2001/10/20 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/20 10:00
PHST- 2001/10/20 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/20 10:00 [entrez]
AID - S0166432801002273 [pii]
AID - 10.1016/s0166-4328(01)00227-3 [doi]
PST - ppublish
SO  - Behav Brain Res. 2001 Oct 15;124(2):161-5. doi: 10.1016/s0166-4328(01)00227-3.