PMID- 11640996
OWN - NLM
STAT- MEDLINE
DCOM- 20020116
LR  - 20190910
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 54
IP  - 2
DP  - 2001 Nov
TI  - Plasma levels of endothelin, lipid peroxides and prostacyclin in diabetic 
      patients with macroangiopathy.
PG  - 129-36
AB  - The prevalence of macroangiopathy is increased in diabetes mellitus. Endothelial 
      cell injury is thought to be an early event leading to atherosclerosis which may 
      be initiated by several factors. We have investigated the relationship between 
      plasma endothelin, lipid peroxide (measured as thiobarbituric acid reacting 
      species (TBARS)) and 6-keto-prostaglandin-F1A (6-keto-PG-F1A) in Type 2 diabetic 
      patients with macroangiopathy. Fifty-three diabetic subjects with macroangiopathy 
      were investigated, together with 50 diabetic and 50 control subjects without 
      evidence of vascular disease. Both the endothelin and TBARS levels were 
      significantly higher in diabetic patients with macroangiopathy (10.8 (8.0-14.4) 
      pmol/l and 5.6 (3.2-9.7) micromol/l, respectively) compared with control subjects 
      (7.6 (5.0-11.0) pmol/l and 4.5 (3.0-6.4) micromol/l, P<0.001) and with diabetic 
      subjects without macroangiopathy (7.4 (4.9-11.2) pmol/l (P<0.001) and 4.9 
      (3.0-8.0) micromol/l (P<0.05)). 6-Keto-PG-F1A levels were significantly decreased 
      in diabetic subjects with macroangiopathy 209 (123-355) pg/ml than in normal 
      subjects 241 (137-425) pg/ml, (P<0.05) and diabetic subjects without 
      macroangiopathy 224 (162-309) pg/ml, (P<0.05). Comparison of levels of endothelin 
      with those of TBARS in macroangiopathy group, showed that endothelin is a more 
      consistent marker of the atherogenic process (P<0.01). In conclusion, we have 
      shown that there are abnormalities of endothelium-derived factors in diabetic 
      patients with macroangiopathy, mainly in endothelin. Furthermore, in this group 
      there was a positive correlation between endothelin and fasting insulin levels.
FAU - Migdalis, I N
AU  - Migdalis IN
AD  - Second Department of Internal Medicine, NIMTS Hospital, 12 Monis Petraki, 11521, 
      Athens, Greece.
FAU - Kalogeropoulou, K
AU  - Kalogeropoulou K
FAU - Iliopoulou, V
AU  - Iliopoulou V
FAU - Triantafilou, P
AU  - Triantafilou P
FAU - Charalabides, J
AU  - Charalabides J
FAU - Mortzos, G
AU  - Mortzos G
FAU - Cordopatis, C
AU  - Cordopatis C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Biomarkers)
RN  - 0 (Endothelins)
RN  - 0 (Lipid Peroxides)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Age of Onset
MH  - Biomarkers/blood
MH  - Diabetic Angiopathies/*blood/pathology
MH  - Endothelins/*blood
MH  - Endothelium, Vascular/pathology
MH  - Epoprostenol/*blood
MH  - Female
MH  - Humans
MH  - Lipid Peroxides/*blood
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Thiobarbituric Acid Reactive Substances/analysis
EDAT- 2001/10/20 10:00
MHDA- 2002/01/17 10:01
CRDT- 2001/10/20 10:00
PHST- 2001/10/20 10:00 [pubmed]
PHST- 2002/01/17 10:01 [medline]
PHST- 2001/10/20 10:00 [entrez]
AID - S0168-8227(01)00275-3 [pii]
AID - 10.1016/s0168-8227(01)00275-3 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2001 Nov;54(2):129-36. doi: 
      10.1016/s0168-8227(01)00275-3.