PMID- 11642675
OWN - NLM
STAT- MEDLINE
DCOM- 20020311
LR  - 20190921
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 46
IP  - 4
DP  - 2001 Oct
TI  - Further experience with intravenous immunoglobulin in women with recurrent 
      miscarriage and a poor prognosis.
PG  - 268-73
AB  - PROBLEM: Women with three or more unexplained miscarriages have a 60% chance of a 
      subsequent live birth. Intravenous immunoglobulin (IVIG) has not been 
      conclusively shown to improve this prognosis. This study assessed the effect of 
      IVIG in patients expected to have a poor outcome if untreated, i.e. women with 
      five or more abortions, who have aborted after paternal leukocyte immunization or 
      who continue to abort despite expressing anti-paternal complement dependent 
      antibody. METHODS: Seventy-six women received IVIG in a dose of 400 mg/kg body 
      weight, in one day (total 30-45 g) in the follicular phase of a cycle in which 
      pregnancy was planned. A booster dose was administered when pregnancy was 
      diagnosed. Their results were compared to an untreated control group of 74 women. 
      RESULTS: Thirty-five (49%) pregnancies in treated women have resulted in live 
      births or passed their previous stages of abortion compared to 23 (31%) in 
      control patients (P = 0.04). CONCLUSIONS: These figures indicate that IVIG may 
      prevent further miscarriages in this poor prognosis population. These figures are 
      especially significant considering the doubt concerning the efficacy of IVIG in 
      patients with three miscarriages and therefore a relatively good prognosis.
FAU - Carp, H J
AU  - Carp HJ
AD  - Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, 
      Israel. carp@netvision.net.il
FAU - Toder, V
AU  - Toder V
FAU - Gazit, E
AU  - Gazit E
FAU - Ahiron, R
AU  - Ahiron R
FAU - Torchinski, A
AU  - Torchinski A
FAU - Mashiach, S
AU  - Mashiach S
FAU - Shoenfeld, Y
AU  - Shoenfeld Y
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Abortion, Habitual/*drug therapy/prevention & control
MH  - Adult
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/*therapeutic use
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy Rate
MH  - Prognosis
EDAT- 2001/10/20 10:00
MHDA- 2002/03/12 10:01
CRDT- 2001/10/20 10:00
PHST- 2001/10/20 10:00 [pubmed]
PHST- 2002/03/12 10:01 [medline]
PHST- 2001/10/20 10:00 [entrez]
AID - 10.1034/j.1600-0897.2001.d01-12.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2001 Oct;46(4):268-73. doi: 
      10.1034/j.1600-0897.2001.d01-12.x.