PMID- 11667980
OWN - NLM
STAT- MEDLINE
DCOM- 20030520
LR  - 20181113
IS  - 1465-9921 (Print)
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Linking)
VI  - 1
IP  - 3
DP  - 2000
TI  - Oxygen-regulated transcription factors and their role in pulmonary disease.
PG  - 159-62
AB  - The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth 
      response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in 
      the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 
      controls the production of interleukin (IL)-6 in vascular endothelial cells, 
      which may have anti-inflammatory activity by counteracting effects of IL-1 and 
      IL-8. EGR-1 controls the production of tissue factor by macrophages, which 
      triggers fibrin deposition in the pulmonary vasculature. HIF-1 activates the 
      expression of the vasoconstrictor endothelin-1 in vascular endothelial cells. 
      Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial 
      smooth muscle cells. HIF-1 might therefore have multiple roles in the 
      pathogenesis of pulmonary vascular remodeling.
FAU - Semenza, G L
AU  - Semenza GL
AD  - Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland, USA. gsemenza@jhmi.edu
LA  - eng
GR  - R01 HL055338/HL/NHLBI NIH HHS/United States
GR  - R01-DK39869/DK/NIDDK NIH HHS/United States
GR  - R01-HL55338/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20001109
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
RN  - 0 (CCAAT-Enhancer-Binding Protein-beta)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - CCAAT-Enhancer-Binding Protein-beta/metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Hypoxia-Inducible Factor 1
MH  - Lung Diseases/*metabolism
MH  - Nuclear Proteins/metabolism
MH  - Oxygen/*metabolism
MH  - Transcription Factors/*metabolism
PMC - PMC59554
EDAT- 2001/10/23 10:00
MHDA- 2003/05/21 05:00
PMCR- 2000/11/09
CRDT- 2001/10/23 10:00
PHST- 2000/09/27 00:00 [received]
PHST- 2000/10/16 00:00 [revised]
PHST- 2000/10/19 00:00 [accepted]
PHST- 2001/10/23 10:00 [pubmed]
PHST- 2003/05/21 05:00 [medline]
PHST- 2001/10/23 10:00 [entrez]
PHST- 2000/11/09 00:00 [pmc-release]
AID - rr27 [pii]
AID - 10.1186/rr27 [doi]
PST - ppublish
SO  - Respir Res. 2000;1(3):159-62. doi: 10.1186/rr27. Epub 2000 Nov 9.