PMID- 11681857
OWN - NLM
STAT- MEDLINE
DCOM- 20011205
LR  - 20071114
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 172
IP  - 1
DP  - 2001 Nov
TI  - Attenuated lesion-induced N-methyl-D-aspartate receptor (NMDAR) plasticity in the 
      dentate gyrus of aged rats following perforant path lesions.
PG  - 244-9
AB  - Young animals demonstrate a significant upregulation of N-methyl-d-aspartate 
      receptor 1 (NMDAR1) in the outer molecular layer (OML) of the dentate gyrus 
      following a total unilateral ablation of the perforant path, and this response 
      presumably facilitates a degree of functional recovery. Aged animals have 
      attenuated responses to lesion-induced synaptic plasticity as compared with young 
      subjects, and in fact display decreased synaptogenesis and sprouting following a 
      unilateral perforant path lesion. To investigate the response of NMDAR1 in the 
      dentate gyrus of aged animals to perforant path ablation, 24-month-old 
      Sprague-Dawley male rats received a unilateral knife cut of the angular bundle. 
      Our results demonstrated that aged animals displayed a blunted response to 
      lesion-induced NMDA receptor-mediated plasticity, suggesting that aged animals 
      have an impaired ability to respond to deafferentation through an increase in 
      NMDA receptor levels in the deafferented zone.
CI  - Copyright 2001 Academic Press.
FAU - Adams, M M
AU  - Adams MM
AD  - Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New 
      York, New York 10029-6574, USA.
FAU - Gazzaley, A H
AU  - Gazzaley AH
FAU - Morrison, J H
AU  - Morrison JH
LA  - eng
GR  - AG06647/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (NMDA receptor A1)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Age Factors
MH  - Aging/*metabolism
MH  - Animals
MH  - Dentate Gyrus/*metabolism
MH  - Fluorescent Antibody Technique
MH  - Male
MH  - Neuronal Plasticity/*physiology
MH  - Perforant Pathway/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
EDAT- 2001/10/30 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/30 10:00
PHST- 2001/10/30 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/30 10:00 [entrez]
AID - S0014-4886(01)97794-5 [pii]
AID - 10.1006/exnr.2001.7794 [doi]
PST - ppublish
SO  - Exp Neurol. 2001 Nov;172(1):244-9. doi: 10.1006/exnr.2001.7794.