PMID- 11682276
OWN - NLM
STAT- MEDLINE
DCOM- 20011228
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 25
IP  - 5 Suppl
DP  - 2001 Nov
TI  - Effect of chronic phenelzine treatment on REM sleep: report of three patients.
PG  - S63-7
AB  - Antidepressants belonging to the class of monoamine oxidase inhibitors (MAOI) 
      such as phenelzine have long been known to drastically suppress REM sleep. Sleep 
      and the electroencephalogram (EEG) in sleep and waking were studied in three 
      depressed patients at regular time intervals before, during and after 6 to 18 
      months of phenelzine treatment. While REM sleep was initially eliminated in all 
      patients, short REM sleep episodes reappeared after three to six months of 
      medication. Total sleep time and EEG slow-wave activity (SWA, spectral power 
      within 0.75-4.5 Hz) in nonREM sleep (stages 1-4) were not changed. In contrast, 
      EEG theta frequency activity (TFA, power within 4.75-8.0 Hz) during a 5-min wake 
      interval recorded prior to the sleep episodes was initially enhanced, and tended 
      to correlate negatively with the percentage of REM sleep (p =.06). This 
      observation indicates that compensatory REM sleep mechanisms may occur in 
      wakefulness during chronic MAOI treatment.
FAU - Landolt, H P
AU  - Landolt HP
AD  - University of California at San Diego, Department of Psychiatry, VA San Diego 
      Healthcare System, San Diego, CA, USA. landolt@pharma.unizh.ch
FAU - de Boer, L P
AU  - de Boer LP
LA  - eng
GR  - M01-RR000827/RR/NCRR NIH HHS/United States
GR  - MH30914/MH/NIMH NIH HHS/United States
GR  - MH38738/MH/NIMH NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Antidepressive Agents)
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - O408N561GF (Phenelzine)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*adverse effects
MH  - Depressive Disorder/drug therapy/physiopathology/psychology
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monoamine Oxidase Inhibitors/*adverse effects
MH  - Phenelzine/*adverse effects
MH  - Polysomnography
MH  - Psychiatric Status Rating Scales
MH  - Sleep, REM/*drug effects
MH  - Wakefulness/drug effects
EDAT- 2001/10/30 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/30 10:00
PHST- 2001/10/30 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/30 10:00 [entrez]
AID - S0893133X01003219 [pii]
AID - 10.1016/S0893-133X(01)00321-9 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2001 Nov;25(5 Suppl):S63-7. doi: 
      10.1016/S0893-133X(01)00321-9.