PMID- 11683344
OWN - NLM
STAT- MEDLINE
DCOM- 20020621
LR  - 20220311
IS  - 0385-8146 (Print)
IS  - 0385-8146 (Linking)
VI  - 28 Suppl
DP  - 2001 May
TI  - Histological findings in biopsies from patients with cytoplasmic-antineutrophil 
      cytoplasmic antibody (cANCA)-positive Wegener's granulomatosis.
PG  - S53-8
AB  - OBJECTIVE: Currently Wegener's granulomatosis (WG) is diagnosed from clinical 
      features, a test for antineutrophil cytoplasmic antibody (ANCA) and histological 
      confirmation. The purpose of our study was to evaluate histological findings, in 
      particular those in the biopsy samples of head and neck region. METHODS: 
      Fifty-one biopsy specimens from 24 WG patients who were confirmed to be positive 
      for cANCA were examined retrospectively. RESULTS: Only 12 biopsies out of 51 
      biopsies (24%) were diagnosed as typical of WG, and diagnosis could be confirmed 
      in only 10 patients (42%) as typical of WG from the results of multiple biopsy 
      specimens. CONCLUSION: In the diagnosis of WG. biopsy can be utilized 
      restrictedly only in the cases when cANCA is negative or clinical symptoms are 
      atypical of WG.
FAU - Maguchi, S
AU  - Maguchi S
AD  - Department of OtolarYngology, Teine Keijinkai Hospital, Sapporo, Japan. 
      smaguchi@fa2.so-net.ne.jp
FAU - Fukuda, S
AU  - Fukuda S
FAU - Takizawa, M
AU  - Takizawa M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis
MH  - Biopsy
MH  - Female
MH  - Granulomatosis with Polyangiitis/immunology/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2001/10/31 10:00
MHDA- 2002/06/22 10:01
CRDT- 2001/10/31 10:00
PHST- 2001/10/31 10:00 [pubmed]
PHST- 2002/06/22 10:01 [medline]
PHST- 2001/10/31 10:00 [entrez]
AID - S0385-8146(01)00072-4 [pii]
AID - 10.1016/s0385-8146(01)00072-4 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2001 May;28 Suppl:S53-8. doi: 10.1016/s0385-8146(01)00072-4.