PMID- 11683586
OWN - NLM
STAT- MEDLINE
DCOM- 20020225
LR  - 20071115
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 16
IP  - 2
DP  - 2001 Oct 21
TI  - The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and 
      chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical 
      granulomas.
PG  - 62-6
AB  - The infiltration of leukocytes into inflammation sites such as observed in human 
      periapical granulomas is considered to be mediated by chemotactic factors. In 
      this study, we examined the presence of chemokine- and chemokine 
      receptor-positive cells in samples obtained from human subjects by means of 
      immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage 
      inflammatory protein (MIP)-1alpha, MIP-1beta and IFN-inducible protein 10 
      (IP-10)-producing cells were present in periapical granulomas. In addition, 
      chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In 
      contrast, no factor expression was observed in clinically healthy periodontal 
      ligament, serving as a negative control. Our findings suggest that these 
      chemokines are responsible for modulating the process of disease, such as human 
      apical periodontitis.
CI  - Copyright 2001 Academic Press.
FAU - Kabashima, H
AU  - Kabashima H
AD  - Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental 
      Science, Kyushu University, Fukuoka 812-8582, Japan.
FAU - Yoneda, M
AU  - Yoneda M
FAU - Nagata, K
AU  - Nagata K
FAU - Hirofuji, T
AU  - Hirofuji T
FAU - Ishihara, Y
AU  - Ishihara Y
FAU - Yamashita, M
AU  - Yamashita M
FAU - Maeda, K
AU  - Maeda K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (CCR3 protein, human)
RN  - 0 (CXCR3 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CXCL10)
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Receptors, CCR3)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR3)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chemokine CCL2/analysis
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CXCL10
MH  - Chemokines/*analysis
MH  - Chemokines, CXC/analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Macrophage Inflammatory Proteins/analysis
MH  - Male
MH  - Middle Aged
MH  - Periapical Granuloma/*immunology/pathology
MH  - Receptors, CCR3
MH  - Receptors, CCR5/analysis
MH  - Receptors, CXCR3
MH  - Receptors, Chemokine/*analysis
EDAT- 2001/10/31 10:00
MHDA- 2002/02/28 10:01
CRDT- 2001/10/31 10:00
PHST- 2001/10/31 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2001/10/31 10:00 [entrez]
AID - S1043-4666(01)90947-0 [pii]
AID - 10.1006/cyto.2001.0947 [doi]
PST - ppublish
SO  - Cytokine. 2001 Oct 21;16(2):62-6. doi: 10.1006/cyto.2001.0947.