PMID- 11683820
OWN - NLM
STAT- MEDLINE
DCOM- 20011205
LR  - 20191105
IS  - 0902-0063 (Print)
IS  - 0902-0063 (Linking)
VI  - 15
IP  - 4
DP  - 2001 Aug
TI  - Hyperhomocysteinemia and transplant coronary artery disease in cardiac transplant 
      recipients.
PG  - 258-62
AB  - BACKGROUND: In cardiac transplant recipients, long-term survival may be limited 
      by transplant coronary artery disease (TxCAD). Hyperhomocysteinemia (Hhcy) has 
      been associated with vascular disease and is common in transplant recipients. The 
      objective of this study was to determine the relationship between fasting 
      homocysteine (Hcy) concentrations and TxCAD in a cohort of cardiac transplant 
      recipients. METHODS: Forty-eight patients more than 5 yr after transplant were 
      recruited from a cohort of 72 consecutive patients with in-depth analysis of 
      homocysteine levels from the Cardiac Transplant Clinic. Early morning fasting 
      blood was obtained, and the plasma separated and frozen within 30 min. Hcy 
      concentrations were determined by high-performance liquid chromatography (HPLC) 
      with pulsed integrated amperometry. Coronary angiograms were reviewed in a 
      blinded fashion. TxCAD was diagnosed, using the most recent angiogram, when a 
      >25% lesion was present anywhere in the coronary tree. RESULTS: Forty-eight 
      patients transplanted between 1985 and 1994 were studied. The mean Hcy 
      concentration for the cohort was 23.5+/-5.0 micromol/L, all patients had 
      homocysteine levels above the upper range of normal (5-15 micromol/L). Hcy 
      concentrations were significantly higher in patients with angiographic evidence 
      of TxCAD: 25.0+/-5.9 vs. 21.9+/-3.4 micromol/L, p=0.03. This effect persisted 
      when covariates were taken into account using logistic regression analysis. 
      CONCLUSIONS: Hhcy is associated with TxCAD. Prospective studies are required to 
      confirm this association and to assess the efficacy of Hcy-lowering therapy in 
      this patient population.
FAU - Miner, S E
AU  - Miner SE
AD  - Division of Cardiology, The Toronto Hospital, University of Toronto, Toronto, 
      Ontario, Canada.
FAU - Cole, D E
AU  - Cole DE
FAU - Evrovski, J
AU  - Evrovski J
FAU - Verma, A
AU  - Verma A
FAU - Daly, P A
AU  - Daly PA
FAU - Ross, H J
AU  - Ross HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Coronary Angiography
MH  - Coronary Disease/*blood/etiology
MH  - Female
MH  - Heart Transplantation/*adverse effects
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications/diagnosis
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
EDAT- 2001/10/31 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/31 10:00
PHST- 2001/10/31 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/31 10:00 [entrez]
AID - 150407 [pii]
AID - 10.1034/j.1399-0012.2001.150407.x [doi]
PST - ppublish
SO  - Clin Transplant. 2001 Aug;15(4):258-62. doi: 10.1034/j.1399-0012.2001.150407.x.