PMID- 11684059
OWN - NLM
STAT- MEDLINE
DCOM- 20020104
LR  - 20220408
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 918
IP  - 1-2
DP  - 2001 Nov 9
TI  - Changes in BDNF-immunoreactive structures in the hippocampal formation of the 
      aged macaque monkey.
PG  - 191-6
AB  - We investigated the changes of brain-derived neurotrophic factor 
      (BDNF)-immunoreactive structures in the hippocampal formation of aged macaques 
      (Macaca fuscata fuscata). At adult stages (10 and 12 years), BDNF 
      immunoreactivity occurred in the neurons of the dentate gyrus, the pyramidal 
      neurons in the CA1, CA2, CA3 subfields and the subiculum, and the neurons in the 
      CA4 subfield and the entorhinal cortex. The apical dendrites were also BDNF 
      immunopositive. In aged monkeys (26, 30 and 32 years), the intensity of the 
      BDNF-immunoreactivity declined significantly in cell bodies and dendrites of the 
      neurons in the hippocampal formation except the CA2 pyramidal neurons. These 
      findings indicate that BDNF is one of the vulnerable signal molecules during the 
      aging process of the primate hippocampal formation.
FAU - Hayashi, M
AU  - Hayashi M
AD  - Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto 
      University, Kanrin, Inuyama, Aichi 484-8506, Japan. hayashi@pti.kyoto-u.ac.jp
FAU - Mistunaga, F
AU  - Mistunaga F
FAU - Ohira, K
AU  - Ohira K
FAU - Shimizu, K
AU  - Shimizu K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Dendrites/metabolism/ultrastructure
MH  - Dentate Gyrus/cytology/metabolism
MH  - Down-Regulation/*physiology
MH  - Entorhinal Cortex/cytology/metabolism
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Glutamic Acid/metabolism
MH  - Hippocampus/cytology/growth & development/*metabolism
MH  - Immunohistochemistry
MH  - Long-Term Potentiation/physiology
MH  - Macaca/anatomy & histology/*metabolism
MH  - Male
MH  - Pyramidal Cells/cytology/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Synaptic Transmission/physiology
EDAT- 2001/10/31 10:00
MHDA- 2002/01/10 10:01
CRDT- 2001/10/31 10:00
PHST- 2001/10/31 10:00 [pubmed]
PHST- 2002/01/10 10:01 [medline]
PHST- 2001/10/31 10:00 [entrez]
AID - S0006-8993(01)03002-5 [pii]
AID - 10.1016/s0006-8993(01)03002-5 [doi]
PST - ppublish
SO  - Brain Res. 2001 Nov 9;918(1-2):191-6. doi: 10.1016/s0006-8993(01)03002-5.