PMID- 11684281
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 25
IP  - 12
DP  - 2001 Dec
TI  - Extramedullary T lymphoid blast crisis representing an additional translocation, 
      t(6;8)(q25;q22) in a patient with Philadelphia-positive chronic myelogenous 
      leukemia after allogeneic bone marrow transplantation.
PG  - 1089-94
AB  - A patient with extramedullary crisis from chronic myelogenous leukemia after 
      allogeneic bone marrow transplantation is reported. A pathological neck lymph 
      node observed after transplantation revealed pre-T lymphoblastic phenotype, and 
      the fluorescence in situ hybridization (FISH) analysis showed recipient type sex 
      chromosomes and bcr/abl fusion gene. The cells represented an additional 
      translocation, t(6;8)(q25;q22). No rearrangements of the T-cell receptor (TCR) 
      beta, gamma or delta chain genes were observed. The absence of TCR rearrangement 
      indicated the clonogenic involvement of pluripotent hematopoietic stem cells by 
      Philadelphia chromosome. Bone marrow specimens at that time showed donor type sex 
      chromosomes and no bcr/abl-positive cells by FISH.
FAU - Okazuka, K
AU  - Okazuka K
AD  - First Department of Internal Medicine, Niigata University School of Medicine, 
      Asahimachi-dori 1, Niigata City 951-8520, Japan.
FAU - Toba, K
AU  - Toba K
FAU - Kawai, K
AU  - Kawai K
FAU - Nikkuni, K
AU  - Nikkuni K
FAU - Tsuchiyama, J
AU  - Tsuchiyama J
FAU - Momoi, A
AU  - Momoi A
FAU - Kanazawa, N
AU  - Kanazawa N
FAU - Nagai, K
AU  - Nagai K
FAU - Suzuki, N
AU  - Suzuki N
FAU - Aizawa, Y
AU  - Aizawa Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - *Blast Crisis
MH  - *Bone Marrow Transplantation
MH  - *Chromosomes, Human, Pair 6
MH  - *Chromosomes, Human, Pair 8
MH  - Gene Rearrangement, T-Lymphocyte
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/pathology
MH  - Lymph Nodes/immunology
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
MH  - Transplantation, Homologous
EDAT- 2001/10/31 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/31 10:00
PHST- 2001/10/31 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/31 10:00 [entrez]
AID - S0145212601000789 [pii]
AID - 10.1016/s0145-2126(01)00078-9 [doi]
PST - ppublish
SO  - Leuk Res. 2001 Dec;25(12):1089-94. doi: 10.1016/s0145-2126(01)00078-9.