PMID- 11684333
OWN - NLM
STAT- MEDLINE
DCOM- 20011218
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 313
IP  - 1-2
DP  - 2001 Nov 2
TI  - Age-related decrease in paired-pulse intracortical inhibition in the human 
      primary motor cortex.
PG  - 33-6
AB  - Using biphasic magnetic stimuli, paired-pulse transcranial magnetic stimulation 
      (TMS) at short interstimulus intervals (ISIs) was employed to investigate 
      age-related changes in the balance between intracortical inhibition and 
      facilitation. In 26 right-handed healthy individuals, motor evoked potentials 
      were recorded from the relaxed right first dorsal interosseus muscle after 
      paired-pulse TMS of the left primary motor hand area. The magnitude of 
      intracortical paired-pulse inhibition at ISIs of 1-5 ms was markedly reduced in 
      elderly individuals, whereas no age effect was observed for intracortical 
      paired-pulse facilitation at ISIs of 11-15 ms. This finding demonstrates that 
      normal aging is associated with a relative decrease in the excitability of 
      intracortical inhibitory circuits. In conclusion, paired-pulse TMS provides a 
      non-invasive means of studying age-related functional changes in the motor 
      cortex.
FAU - Peinemann, A
AU  - Peinemann A
AD  - Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, D-81675 
      Munich, Germany. alexander.peinemann@neuro.med.tu-muenchen.de
FAU - Lehner, C
AU  - Lehner C
FAU - Conrad, B
AU  - Conrad B
FAU - Siebner, H R
AU  - Siebner HR
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Electric Stimulation
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Magnetics
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition/*physiology
EDAT- 2001/10/31 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/31 10:00
PHST- 2001/10/31 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/31 10:00 [entrez]
AID - S030439400102239X [pii]
AID - 10.1016/s0304-3940(01)02239-x [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Nov 2;313(1-2):33-6. doi: 10.1016/s0304-3940(01)02239-x.