PMID- 11685098
OWN - NLM
STAT- MEDLINE
DCOM- 20020130
LR  - 20191105
IS  - 0883-5993 (Print)
IS  - 0883-5993 (Linking)
VI  - 16
IP  - 4
DP  - 2001 Oct
TI  - Severe alveolar proteinosis following chemotherapy for acute myeloid leukemia in 
      a lung allograft recipient.
PG  - 307-9
AB  - A 64-year-old man was diagnosed with acute myeloid leukemia (AML) 5 years 
      following single lung transplantation performed for severe pulmonary hypertension 
      from scleroderma. Chemotherapy for treatment of AML with fludarabine, cytosine 
      arabinoside, G-CSF (FLAG) regimen was initiated. Despite intensive antibiotic 
      treatment for a presumptive diagnosis of bacterial pneumonia, the patient 
      developed acute respiratory failure and died before a complete cycle of 
      chemotherapy could be administered. At autopsy, both native and allograft lungs 
      showed widespread alveolar proteinosis that was determined as the main cause of 
      acute respiratory failure. Alveolar proteinosis, a potentially treatable disease, 
      should be considered in the radiologic differential diagnosis of diffuse lung 
      disease in this clinical setting.
FAU - Du, E Z
AU  - Du EZ
AD  - Department of Pathology, University of California San Diego, School of Medicine, 
      San Diego, CA, USA.
FAU - Yung, G L
AU  - Yung GL
FAU - Le, D T
AU  - Le DT
FAU - Masliah, E
AU  - Masliah E
FAU - Yi, E S
AU  - Yi ES
FAU - Friedman, P J
AU  - Friedman PJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Thorac Imaging
JT  - Journal of thoracic imaging
JID - 8606160
RN  - 04079A1RDZ (Cytarabine)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - FA2DM6879K (Vidarabine)
RN  - FLAG protocol
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*adverse effects
MH  - Cytarabine/*adverse effects
MH  - Diagnosis, Differential
MH  - Fatal Outcome
MH  - Granulocyte Colony-Stimulating Factor/*adverse effects
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*complications/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Alveolar Proteinosis/*diagnostic imaging/*etiology
MH  - Tomography, X-Ray Computed
MH  - Vidarabine/*adverse effects/analogs & derivatives
EDAT- 2001/10/31 10:00
MHDA- 2002/01/31 10:01
CRDT- 2001/10/31 10:00
PHST- 2001/10/31 10:00 [pubmed]
PHST- 2002/01/31 10:01 [medline]
PHST- 2001/10/31 10:00 [entrez]
AID - 10.1097/00005382-200110000-00014 [doi]
PST - ppublish
SO  - J Thorac Imaging. 2001 Oct;16(4):307-9. doi: 10.1097/00005382-200110000-00014.