PMID- 11686894
OWN - NLM
STAT- MEDLINE
DCOM- 20020103
LR  - 20220321
IS  - 1465-9921 (Print)
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Linking)
VI  - 2
IP  - 5
DP  - 2001
TI  - Tumor necrosis factor-alpha and muscle wasting: a cellular perspective.
PG  - 269-72
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a polypeptide cytokine that has been 
      associated with muscle wasting and weakness in inflammatory disease. Despite its 
      potential importance in muscle pathology, the direct effects of TNF-alpha on 
      skeletal muscle have remained undefined until recently. Studies of cultured 
      muscle cells indicate that TNF-alpha disrupts the differentiation process and can 
      promote catabolism in mature cells. The latter response appears to be mediated by 
      reactive oxygen species and nuclear factor-kappaB which upregulate 
      ubiquitin/proteasome activity. This commentary outlines our current understanding 
      of TNF-alpha effects on skeletal muscle and the mechanism of TNF-alpha action.
FAU - Reid, M B
AU  - Reid MB
AD  - Pulmonary Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 
      77030, USA. reid@bcm.tmc.edu
FAU - Li, Y P
AU  - Li YP
LA  - eng
GR  - R01 HL059878/HL/NHLBI NIH HHS/United States
GR  - HL-59878/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20010712
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
RN  - 0 (Muscle Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Muscle Proteins/metabolism
MH  - Muscle Weakness/pathology
MH  - Muscle, Skeletal/*pathology
MH  - Signal Transduction/physiology
MH  - Tumor Necrosis Factor-alpha/*physiology
MH  - Wasting Syndrome/metabolism/*pathology
PMC - PMC59514
EDAT- 2001/11/01 10:00
MHDA- 2002/01/05 10:01
PMCR- 2001/07/12
CRDT- 2001/11/01 10:00
PHST- 2001/04/30 00:00 [received]
PHST- 2001/06/02 00:00 [revised]
PHST- 2001/06/12 00:00 [accepted]
PHST- 2001/11/01 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/01 10:00 [entrez]
PHST- 2001/07/12 00:00 [pmc-release]
AID - rr67 [pii]
AID - 10.1186/rr67 [doi]
PST - ppublish
SO  - Respir Res. 2001;2(5):269-72. doi: 10.1186/rr67. Epub 2001 Jul 12.