PMID- 11688902
OWN - NLM
STAT- MEDLINE
DCOM- 20020212
LR  - 20190901
IS  - 0300-8126 (Print)
IS  - 0300-8126 (Linking)
VI  - 29
IP  - 5
DP  - 2001 Oct
TI  - Nutritional status impairments in HIV-infected patients are associated with 
      increased TNF-alpha and IL-6 serum levels but not with viral load.
PG  - 257-61
AB  - BACKGROUND: Cytokines may alter metabolic pathways and contribute to malnutrition 
      among human immunodefiency virus (HIV)-positive individuals. PATIENTS AND 
      METHODS: Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble 
      IL-2 receptors (sIL-2R), beta2-microglobulin serum levels and plasma viral load 
      of 45 HIV-positive patients were determined and correlated to nutritional status 
      impairment. Patients were grouped by CD4 counts into categories I (< 200/microl), 
      II (200-499/microl), III (> or = 500/microl). There were 15 healthy controls. A 
      nutritional grading system, based on anthropometric and laboratory data, was 
      devised. Scores ranged from 0 to 5 (eutrophic to malnutrition). RESULTS: AIDS 
      patients' cytokines and immune marker levels were significantly higher than those 
      of the controls, but not always higher than those of other categories. AIDS 
      patients had higher nutritional deficit grades than category III (p < 0.05) or 
      the controls (p < 0.02) which, except for viral load, correlated with the 
      parameters studied. CONCLUSION: Nutritional status impairments in HIV-positive 
      individuals were associated with immune activation but not with viral load.
FAU - Galhardo, M C
AU  - Galhardo MC
AD  - Centro de Pesquisa Hospital Evandro Chagas, Fundacao Oswaldo Cruz, Rio de 
      Janeiro, Brazil. mclara@cpqhec.fiocruz.br
FAU - de Carvalho, M G
AU  - de Carvalho MG
FAU - Georg, I
AU  - Georg I
FAU - Perez, M
AU  - Perez M
FAU - Morgado, M G
AU  - Morgado MG
FAU - de Azevedo, L M
AU  - de Azevedo LM
FAU - Sampaio, E P
AU  - Sampaio EP
FAU - Sarno, E N
AU  - Sarno EN
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Infection
JT  - Infection
JID - 0365307
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - HIV Infections/*complications/immunology
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Nutrition Disorders/*physiopathology
MH  - *Nutritional Status
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - Viral Load
EDAT- 2001/11/02 10:00
MHDA- 2002/02/13 10:01
CRDT- 2001/11/02 10:00
PHST- 2001/11/02 10:00 [pubmed]
PHST- 2002/02/13 10:01 [medline]
PHST- 2001/11/02 10:00 [entrez]
AID - 10.1007/s15010-001-1074-1 [doi]
PST - ppublish
SO  - Infection. 2001 Oct;29(5):257-61. doi: 10.1007/s15010-001-1074-1.