PMID- 11688998
OWN - NLM
STAT- MEDLINE
DCOM- 20011218
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 288
IP  - 4
DP  - 2001 Nov 9
TI  - Lipopolysaccharide regulates constitutive and inducible transcription factor 
      activities differentially in vivo in the rat.
PG  - 927-32
AB  - The pathophysiology of septic shock is characterized by the induction of multiple 
      proinflammatory genes and their products. Transcription factors play key roles in 
      the transcription of these genes. Transcription factors may play important roles 
      in the pathophysiology of septic shock. However, little information is available 
      regarding the in vivo transcription factor activities during sepsis. We have 
      studied the in vivo effects of LPS on the DNA binding activities of transcription 
      factors Sp1 (promoter selective transcription factor), AP-2 (activating 
      protein-2), AP-1 (activating protein-1), NF-kappaB (nuclear factor kappa B), and 
      CREB (cAMP response element binding protein). We found that LPS up-regulated the 
      DNA binding activity of inducible transcription factors AP-1, NF-kappaB, and CREB 
      in a time-dependent manner, but down-regulated the DNA binding activity of 
      constitutive transcription factors Sp1 and AP-2. Thus, LPS regulates the 
      inducible and constitutive transcription factors differentially under in vivo 
      conditions.
CI  - Copyright 2001 Academic Press.
FAU - Ye, X
AU  - Ye X
AD  - Division of Pulmonary and Critical Care Medicine, Long Island Campus for the 
      Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
FAU - Liu, S F
AU  - Liu SF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-kappa B)
RN  - 0 (Sp1 Transcription Factor)
RN  - 0 (Transcription Factor AP-1)
RN  - 0 (Transcription Factor AP-2)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - DNA/genetics/metabolism
MH  - DNA-Binding Proteins/metabolism
MH  - Down-Regulation/*drug effects
MH  - Electrophoretic Mobility Shift Assay
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - NF-kappa B/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Response Elements/genetics
MH  - Sepsis/genetics/*metabolism
MH  - Sp1 Transcription Factor/metabolism
MH  - Time Factors
MH  - Transcription Factor AP-1/metabolism
MH  - Transcription Factor AP-2
MH  - Transcription Factors/*metabolism
MH  - Up-Regulation/*drug effects
EDAT- 2001/11/02 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/02 10:00
PHST- 2001/11/02 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/02 10:00 [entrez]
AID - S0006-291X(01)95883-8 [pii]
AID - 10.1006/bbrc.2001.5883 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2001 Nov 9;288(4):927-32. doi: 
      10.1006/bbrc.2001.5883.