PMID- 11689285
OWN - NLM
STAT- MEDLINE
DCOM- 20011212
LR  - 20240109
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 174
IP  - 2
DP  - 2001 Dec 28
TI  - Molecular basis for the contribution of the antioxidant responsive element to 
      cancer chemoprevention.
PG  - 103-13
AB  - This article provides an overview of the mechanisms by which cancer 
      chemopreventive blocking agents increase the expression of detoxication and 
      antioxidant genes. These agents all appear capable of transcriptionally 
      activating a gene battery that includes NAD(P)H:quinone oxidoreductase, aldo-keto 
      reductases, glutathione S-transferases, gamma-glutamylcysteine synthetase, 
      glutathione synthetase and heme oxygenase. Gene induction occurs through the 
      antioxidant responsive element (ARE), a process that is dependent on the Nuclear 
      Factor-Erythroid 2p45-related factors, Nrf1 and Nrf2. Under basal conditions, 
      these basic region leucine zipper (bZIP) transcription factors are located in the 
      cytoplasm of the cell bound to Keap1, and upon challenge with inducing agents, 
      they are released from Keap1 and translocate to the nucleus. Within the nucleus, 
      Nrf1 and Nrf2 are recruited to the ARE as heterodimers with either small Maf 
      proteins, FosB, c-Jun, JunD, activating transcription factor 2 (ATF2) or ATF4. 
      The role of protein kinases in transducing chemical stress signals to the bZIP 
      factors that affect gene induction through the ARE is discussed.
FAU - Hayes, J D
AU  - Hayes JD
AD  - Biomedical Research Centre, Ninewells Hospital and Medical School, University of 
      Dundee, Dundee DD1 9SY, Scotland, UK. hayes@icrf.icnet.uk
FAU - McMahon, M
AU  - McMahon M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Antioxidants)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - 0 (NRF1 protein, human)
RN  - 0 (Nuclear Respiratory Factor 1)
RN  - 0 (Nuclear Respiratory Factors)
RN  - 0 (Trans-Activators)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - DNA-Binding Proteins/*metabolism
MH  - Humans
MH  - Leucine Zippers/physiology
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - NF-E2-Related Factor 2
MH  - Neoplasms/metabolism/*prevention & control
MH  - Nuclear Respiratory Factor 1
MH  - Nuclear Respiratory Factors
MH  - Oxidoreductases/metabolism
MH  - Trans-Activators/*metabolism
RF  - 83
EDAT- 2001/11/02 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/02 10:00
PHST- 2001/11/02 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/02 10:00 [entrez]
AID - S0304383501006954 [pii]
AID - 10.1016/s0304-3835(01)00695-4 [doi]
PST - ppublish
SO  - Cancer Lett. 2001 Dec 28;174(2):103-13. doi: 10.1016/s0304-3835(01)00695-4.