PMID- 11689885
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20171116
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 7
IP  - 11
DP  - 2001 Nov
TI  - Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, 
      extracellular calcium influx and chemotaxis in neutrophils and is required for 
      bacterial clearance in vivo.
PG  - 1209-16
AB  - Cyclic ADP-ribose is believed to be an important calcium-mobilizing second 
      messenger in invertebrate, mammalian and plant cells. CD38, the 
      best-characterized mammalian ADP-ribosyl cyclase, is postulated to be an 
      important source of cyclic ADP-ribose in vivo. Using CD38-deficient mice, we 
      demonstrate that the loss of CD38 renders mice susceptible to bacterial 
      infections due to an inability of CD38-deficient neutrophils to directionally 
      migrate to the site of infection. Furthermore, we show that cyclic ADP-ribose can 
      directly induce intracellular Ca++ release in neutrophils and is required for 
      sustained extracellular Ca++ influx in neutrophils that have been stimulated by 
      the bacterial chemoattractant, formyl-methionyl-leucyl-phenylalanine (fMLP). 
      Finally, we demonstrate that neutrophil chemotaxis to fMLP is dependent on Ca++ 
      mobilization mediated by cyclic ADP-ribose. Thus, CD38 controls neutrophil 
      chemotaxis to bacterial chemoattractants through its production of cyclic 
      ADP-ribose, and acts as a critical regulator of inflammation and innate immune 
      responses.
FAU - Partida-Sanchez, S
AU  - Partida-Sanchez S
AD  - Trudeau Institute, Saranac Lake, New York, USA.
FAU - Cockayne, D A
AU  - Cockayne DA
FAU - Monard, S
AU  - Monard S
FAU - Jacobson, E L
AU  - Jacobson EL
FAU - Oppenheimer, N
AU  - Oppenheimer N
FAU - Garvy, B
AU  - Garvy B
FAU - Kusser, K
AU  - Kusser K
FAU - Goodrich, S
AU  - Goodrich S
FAU - Howard, M
AU  - Howard M
FAU - Harmsen, A
AU  - Harmsen A
FAU - Randall, T D
AU  - Randall TD
FAU - Lund, F E
AU  - Lund FE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Membrane Glycoproteins)
RN  - 0U46U6E8UK (NAD)
RN  - 119340-53-3 (Cyclic ADP-Ribose)
RN  - 15662-33-6 (Ryanodine)
RN  - 20762-30-5 (Adenosine Diphosphate Ribose)
RN  - 52977-37-4 (nicotinamide-8-bromoadenine dinucleotide)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - EC 3.2.2.5 (ADP-ribosyl Cyclase)
RN  - EC 3.2.2.5 (Cd38 protein, mouse)
RN  - EC 3.2.2.5 (NAD+ Nucleosidase)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
CIN - Nat Med. 2001 Nov;7(11):1182-4. PMID: 11689878
CIN - Nat Med. 2002 Apr;8(4):307; author reply 307-8. PMID: 11927913
MH  - ADP-ribosyl Cyclase
MH  - ADP-ribosyl Cyclase 1
MH  - Adenosine Diphosphate Ribose/*analogs & derivatives/*biosynthesis
MH  - Animals
MH  - *Antigens, CD
MH  - Antigens, Differentiation/genetics/*metabolism
MH  - Calcium Signaling/*physiology
MH  - Chemotaxis, Leukocyte/drug effects/*physiology
MH  - Cyclic ADP-Ribose
MH  - Lymphoid Tissue/enzymology/immunology
MH  - Membrane Glycoproteins
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - NAD/*analogs & derivatives/pharmacology
MH  - NAD+ Nucleosidase/genetics/*metabolism
MH  - Neutrophils/drug effects/immunology/*physiology
MH  - Pneumococcal Infections/etiology
MH  - Ryanodine/pharmacology
MH  - Streptococcus pneumoniae/immunology
EDAT- 2001/11/02 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/02 10:00
PHST- 2001/11/02 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/02 10:00 [entrez]
AID - nm1101-1209 [pii]
AID - 10.1038/nm1101-1209 [doi]
PST - ppublish
SO  - Nat Med. 2001 Nov;7(11):1209-16. doi: 10.1038/nm1101-1209.