PMID- 11692012
OWN - NLM
STAT- MEDLINE
DCOM- 20030320
LR  - 20220318
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 32
IP  - 11
DP  - 2001 Nov
TI  - Cerebral blood flow in patients with chronic heart failure before and after heart 
      transplantation.
PG  - 2530-3
AB  - BACKGROUND AND PURPOSE: Arterial blood pressure and cardiac output are often 
      reduced in patients with chronic heart failure (CHF). Counterregulatory 
      mechanisms with increased neurohormonal activation and changes in the 
      distribution of cardiac output are assumed to secure vital organ perfusion. 
      However, clinical examination of patients with CHF frequently reveals 
      neurological symptoms with dizziness and memory problems, suggesting altered 
      brain perfusion. In this study we determined whether cerebral blood flow (CBF) is 
      reduced in patients with New York Heart Association (NYHA) functional class III 
      and IV (n=12) compared with healthy control subjects (n=12). Furthermore, we 
      examined whether heart transplantation (n=5) could restore CBF. METHODS: CBF was 
      estimated by single-photon emission computed tomography and (133)Xe as tracer, 
      and middle cerebral artery velocity was measured by transcranial Doppler 
      ultrasound. RESULTS: In the CHF patients, CBF was 36+/-1 mL/min per 100 g, 
      corresponding to a 31% reduction compared with the control group (52+/-5 mL/min 
      per 100 g) (P<0.05). After heart transplantation, CBF increased from 35+/-3 
      mL/min per 100 g before transplantation to 50+/-3 mL/min per 100 g within the 
      first postoperative month (P<0.05). CONCLUSIONS: We conclude that CBF is 
      substantially, but reversibly, reduced in patients with NYHA class III/IV heart 
      failure. This phenomenon suggests that redistribution of cardiac output 
      inadequately secures brain perfusion in patients with severe CHF.
FAU - Gruhn, N
AU  - Gruhn N
AD  - Department of Medicine, Division of Cardiology, Rigshospitalet, University of 
      Copenhagen, Denmark.
FAU - Larsen, F S
AU  - Larsen FS
FAU - Boesgaard, S
AU  - Boesgaard S
FAU - Knudsen, G M
AU  - Knudsen GM
FAU - Mortensen, S A
AU  - Mortensen SA
FAU - Thomsen, G
AU  - Thomsen G
FAU - Aldershvile, J
AU  - Aldershvile J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Blood Flow Velocity
MH  - Blood Pressure
MH  - Carbon Dioxide/analysis
MH  - *Cerebrovascular Circulation
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/diagnosis/*physiopathology/*surgery
MH  - *Heart Transplantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Middle Cerebral Artery/diagnostic imaging
MH  - Tomography, Emission-Computed
MH  - Ultrasonography, Doppler, Transcranial
EDAT- 2001/11/03 10:00
MHDA- 2003/03/21 04:00
CRDT- 2001/11/03 10:00
PHST- 2001/11/03 10:00 [pubmed]
PHST- 2003/03/21 04:00 [medline]
PHST- 2001/11/03 10:00 [entrez]
AID - 10.1161/hs1101.098360 [doi]
PST - ppublish
SO  - Stroke. 2001 Nov;32(11):2530-3. doi: 10.1161/hs1101.098360.