PMID- 11692036
OWN - NLM
STAT- MEDLINE
DCOM- 20030320
LR  - 20220408
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 32
IP  - 11
DP  - 2001 Nov
TI  - Monocyte chemoattractant protein-1 is increased in the cerebrospinal fluid of 
      patients with ischemic stroke.
PG  - 2695-6
AB  - BACKGROUND AND PURPOSE: Animal models of stroke have shown that focal cerebral 
      ischemia results in an increased expression of several cytokines and chemokines 
      that precedes leukocyte infiltration into ischemic lesions. The infiltrated 
      leukocytes are thought to contribute to tissue injury in stroke. Monocyte 
      chemoattractant protein-1 (MCP-1) may play an important role in 
      monocyte/macrophage infiltration in stroke patients. METHODS: We studied MCP-1 
      level in sera and the cerebrospinal fluid of 23 ischemic stroke patients 24 hours 
      after the onset of neurological symptoms and compared the results with 15 control 
      patients with tension headache. The MCP-1 level was determined by ELISA. RESULTS: 
      There was a significant increase of cerebrospinal fluid MCP-1 level in the 
      studied stroke patients in comparison with the control group. The serum level of 
      MCP-1 did not differ from that of control patients. CONCLUSIONS: Our results 
      suggest that MCP-1 may play a role in the inflammatory reaction during the early 
      phase of ischemic stroke.
FAU - Losy, J
AU  - Losy J
AD  - Department of Clinical Neuroimmunology, University School of Medicine, Polish 
      Academy of Sciences, Poznan, Poland. jlosy@mail.usoms.poznan.pl
FAU - Zaremba, J
AU  - Zaremba J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Brain Ischemia/blood/*cerebrospinal fluid
MH  - Chemokine CCL2/blood/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Male
MH  - Stroke/blood/*cerebrospinal fluid
EDAT- 2001/11/03 10:00
MHDA- 2003/03/21 04:00
CRDT- 2001/11/03 10:00
PHST- 2001/11/03 10:00 [pubmed]
PHST- 2003/03/21 04:00 [medline]
PHST- 2001/11/03 10:00 [entrez]
AID - 10.1161/hs1101.097380 [doi]
PST - ppublish
SO  - Stroke. 2001 Nov;32(11):2695-6. doi: 10.1161/hs1101.097380.