PMID- 11692146
OWN - NLM
STAT- MEDLINE
DCOM- 20020110
LR  - 20191105
IS  - 1219-4956 (Print)
IS  - 1219-4956 (Linking)
VI  - 7
IP  - 3
DP  - 2001
TI  - Effect of earthworm (G-90) extract on formation and lysis of clots originated 
      from venous blood of dogs with cardiopathies and with malignant tumors.
PG  - 197-202
AB  - The stability of homeostasis is important to keep a balance between coagulation 
      and fibrinolysis. A disorder of homeostasis leads to different physiological 
      changes and causes different diseases such as cardiopathies and malignant tumors. 
      Cardiopathies is characterized by a hypercoagulation. In the malignant tumors, 
      besides the hypercoagulation due to plasminogen activators (PA) formed inside the 
      tumor, a disorder of homeostasis leads also to acceleration of the fibrinolysis. 
      The variety of internal and external factors in both cases determine the 
      deviation of time for the clots formation, as well as the lyses of blood and 
      fibrin clots. In this study the venous blood as well as the blood and the fibrin 
      clots, derived from healthy dogs, the dogs with cardiopathies and with malignant 
      tumors, were examined for the time of coagulation and fibrinolysis by adding 
      different substances. In these experiments we used a glycolipoprotein extract 
      from earthworm tissue homogenate (G-90) and the proteolytic enzymes P I and P II, 
      isolated from G-90. The efficacy of the tested substances was comparable with the 
      clinically administered anticoagulants. The most significant differences in 
      clotting time among the three tested groups of dogs were obtained by application 
      of the original G-90. The results suggest a possibility that G-90, along with the 
      fibrinolytic enzymes and other biologically active factors, also contains a 
      factor that decelerates the formation of clot in a specific medium, such as the 
      blood from the dogs with malignant tumors.
FAU - Popovic, M
AU  - Popovic M
AD  - Department of Biology, Faculty of Veterinary Medicine, Ruder Bockovic Institute, 
      Heinzelova 55, 10000 Zagreb, Croatia. mpopovic@vef.hr
FAU - Hrcenjak, T M
AU  - Hrcenjak TM
FAU - Babic, T
AU  - Babic T
FAU - Kos, J
AU  - Kos J
FAU - Grdisa, M
AU  - Grdisa M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Glycoproteins)
RN  - 0 (Tissue Extracts)
RN  - EC 3.4.- (Streptokinase)
SB  - IM
MH  - Animals
MH  - Blood Coagulation Tests
MH  - Cardiomyopathy, Dilated/*veterinary
MH  - Dog Diseases/*blood
MH  - Dogs
MH  - Erythrocytes/metabolism
MH  - Female
MH  - Fibrinolysis/*drug effects
MH  - Fibrinolytic Agents/isolation & purification/*pharmacology
MH  - Glycoproteins/pharmacology
MH  - Mammary Neoplasms, Animal/*blood
MH  - Oligochaeta/*chemistry
MH  - Streptokinase/metabolism
MH  - Tissue Extracts/isolation & purification/*pharmacology
MH  - Veins
EDAT- 2001/11/03 10:00
MHDA- 2002/01/11 10:01
CRDT- 2001/11/03 10:00
PHST- 2001/11/03 10:00 [pubmed]
PHST- 2002/01/11 10:01 [medline]
PHST- 2001/11/03 10:00 [entrez]
AID - PAOR.2001.7.3.0197 [pii]
AID - 10.1007/BF03032349 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2001;7(3):197-202. doi: 10.1007/BF03032349.