PMID- 11692215
OWN - NLM
STAT- MEDLINE
DCOM- 20020124
LR  - 20211203
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 14
IP  - 5
DP  - 2001 Sep
TI  - Long-term survival of rat cardiac allografts by intrathymic plus portal venous 
      injections of donor bone marrow cells and short-term tacrolimus 
      immunosuppression.
PG  - 311-9
AB  - Intrathymic (IT) or portal venous (PV) injection of donor antigens has been shown 
      to prolong organ acceptance in low responder rat strain combinations. We 
      determined whether a combination of these strategies would prolong cardiac 
      allograft survival in high responder combinations. Wistar Furth rats received 1 x 
      10(8) ACI rat bone marrow cells (BMCs) via IT, intravenous (IV), PV, IV + PV, IT 
      + IV or IT + PV route at the time of ACI cardiac transplantation. Without 
      tacrolimus (FK), all grafts were acutely rejected. With FK immunosuppression (1.5 
      mg/kg per day, I. M., days 0-4), single BMC injection did not increase graft 
      survival beyond 93 days, whereas 70% of grafts survived indefinitely ( > 150 
      days) when IT and PV BMCs were combined. Animals receiving IT and PV BMCs also 
      had less allograft vasculopathy. Thus, IT and PV injections of donor BMCs under a 
      brief course of FK synergistically improve cardiac allograft survival.
FAU - Fukada, J
AU  - Fukada J
AD  - Department of Surgery, University of Miami School of Medicine, Jackson Memorial 
      Hospital, 1611 N.W. 12th Avenue, Miami, Florida 33136, USA.
FAU - Kurimoto, Y
AU  - Kurimoto Y
FAU - Ruiz, P
AU  - Ruiz P
FAU - Aitouche, A
AU  - Aitouche A
FAU - Zeevi, A
AU  - Zeevi A
FAU - Li, S
AU  - Li S
FAU - Kubota, T
AU  - Kubota T
FAU - Pham, S M
AU  - Pham SM
LA  - eng
GR  - R01 HL63426-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (Immunosuppressive Agents)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Animals
MH  - *Bone Marrow Transplantation
MH  - Graft Survival/*immunology
MH  - Heart Transplantation/*immunology
MH  - Immunosuppression Therapy/methods
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Male
MH  - Rats
MH  - Rats, Inbred ACI
MH  - Rats, Inbred WF
MH  - Tacrolimus/*therapeutic use
MH  - Time Factors
MH  - Transplantation, Homologous
EDAT- 2001/11/03 10:00
MHDA- 2002/01/25 10:01
CRDT- 2001/11/03 10:00
PHST- 2001/11/03 10:00 [pubmed]
PHST- 2002/01/25 10:01 [medline]
PHST- 2001/11/03 10:00 [entrez]
AID - 10.1007/s001470100341 [doi]
PST - ppublish
SO  - Transpl Int. 2001 Sep;14(5):311-9. doi: 10.1007/s001470100341.