PMID- 11694032
OWN - NLM
STAT- MEDLINE
DCOM- 20020412
LR  - 20191105
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 23
IP  - 3
DP  - 2001 Aug
TI  - Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine 
      model.
PG  - 423-35
AB  - We studied the effect of aqueous extract of Prunella vulgaris (Labiatae) (PVAE) 
      on immediate-type allergic reactions. PVAE (0.005 to 1 g/kg) dose-dependently 
      inhibited systemic anaphylactic shock induced by compound 48/ 80 in rats. When 
      PVAE was given as pretreatment, at concentrations ranging from 0.005 to 1 g/kg, 
      the serum histamine levels induced by compound 48/ 80 were reduced in a 
      dose-dependent manner. PVAE (0.001 to 1 g/kg) inhibited the passive cutaneous 
      anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. 
      PVAE also inhibited the histamine release induced by compound 48/80 or anti-DNP 
      IgE from the rat peritoneal mast cells (RPMC). The level of cyclic AMP in RPMC, 
      when PVAE was added, significantly increased, compared with that of normal 
      control. Moreover, PVAE (0.01 and 0.1 mg/ml) had a significant inhibitory effect 
      on anti-DNP IgE-mediated tumor necrosis factor-alpha production from RPMC. These 
      results indicate that PVAE inhibits immediate-type allergic reactions in rats.
FAU - Shin, T Y
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Chonju, Chonbuk, South Korea.
FAU - Kim, Y K
AU  - Kim YK
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Anaphylaxis/chemically induced/prevention & control
MH  - Animals
MH  - Cyclic AMP/metabolism
MH  - Dinitrobenzenes/immunology
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/*prevention & control
MH  - Immunoglobulin E/administration & dosage
MH  - *Lamiaceae
MH  - Male
MH  - Mast Cells/drug effects/immunology
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/toxicity
EDAT- 2001/11/06 10:00
MHDA- 2002/04/16 10:01
CRDT- 2001/11/06 10:00
PHST- 2001/11/06 10:00 [pubmed]
PHST- 2002/04/16 10:01 [medline]
PHST- 2001/11/06 10:00 [entrez]
AID - 10.1081/iph-100107341 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2001 Aug;23(3):423-35. doi: 10.1081/iph-100107341.