PMID- 11694248
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20190706
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 313
IP  - 1-2
DP  - 2001 Nov
TI  - Measurement of growth hormone, insulin-like growth factor I and their binding 
      proteins: the clinical aspects.
PG  - 119-23
AB  - BACKGROUND: Growth hormone (GH) secreted from the pituitary stimulates the 
      production of insulin-like growth factor I (IGF-I) from the liver and 
      extrahepatic tissues, which in turn regulates tissue proliferation and 
      differentiation in an endocrine or autocrine/paracrine manner. Both GH and IGF-I 
      circulates as complexes with specific binding proteins. The GH binding protein 
      (GHBP) corresponds to the extracellular, ligand-binding domain of the GH 
      receptors in tissues and its serum concentration may reflect the status of the 
      tissue receptors. Most serum IGF-I associates with IGF binding protein 3 
      (IGFBP-3) and another protein, the acid labile subunit (ALS). Like IGF-I, serum 
      concentrations of IGFBP-3 and ALS are tightly regulated by GH. GH secretion (both 
      spontaneous and stimulated), IGF-I, IGFBP-3, and ALS have been assessed as 
      potential biochemical markers for diagnosis of GH-related disorders. CONCLUSIONS: 
      In acromegaly, IGF-I is the most reliable marker. The peak GH response to insulin 
      tolerance test is the diagnostic test of choice, GH deficiency. GHBP has no 
      diagnostic value in acromegaly or GH deficiency. However, it may be a potential 
      biochemical marker for GH insensitivity syndrome as serum GHBP concentrations are 
      undetectable or reduced in >75% of these patients. Other biochemical tests may 
      also prove to be useful in these disorders, but require further validation.
FAU - Leung, K C
AU  - Leung KC
AD  - Pituitary Research Unit, Garvan Institute of Medical Research, St. Vincent's 
      Hospital, 384 Victoria Street, Darlinghurst, NSW 2010, Sydney, Australia. 
      k.leung@garvan.unsw.edu.au
FAU - Ho, K K
AU  - Ho KK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Adult
MH  - Growth Hormone/*blood/deficiency
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Proteins/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
RF  - 43
EDAT- 2001/11/06 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/06 10:00
PHST- 2001/11/06 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/06 10:00 [entrez]
AID - S0009898101006623 [pii]
AID - 10.1016/s0009-8981(01)00662-3 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2001 Nov;313(1-2):119-23. doi: 10.1016/s0009-8981(01)00662-3.