PMID- 11696222
OWN - NLM
STAT- MEDLINE
DCOM- 20020214
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 58
IP  - 2
DP  - 2001 Aug
TI  - Heat shock protein 70 gene polymorphism in Japanese patients with multiple 
      sclerosis.
PG  - 93-6
AB  - Despite the strength of the association of multiple sclerosis (MS) and human 
      leukocyte antigen (HLA)-DR2, other genetic elements could have a role in the 
      pathophysiology of MS. We investigated possible associations with polymorphic 
      susceptibility genes located within the HLA complex, i.e., heat-shock protein 
      (HSP)70-1, HSP70-2, and HSP70-hom in Japanese patients with MS. Furthermore, we 
      analyzed the influence of HSP70 gene polymorphisms on the severity of the 
      disease, clinical course, magnetic resonance imaging findings, and oligoclonal 
      bands in the cerebrospinal fluid, and HLA in MS patients. The results of the 
      present study indicated that there were no significant differences in the 
      distribution of all HSP70 genotypes and allele frequencies between Japanese MS 
      patients and controls. In MS patients, there were no associations between HSP70 
      gene polymorphisms and the clinical data. Moreover, there were no significant 
      differences in HSP70 genotype or allele frequencies between MS patients positive 
      for HLA-DRB1*1501 alleles and matched controls. Our data indicate that HSP70 gene 
      polymorphisms are not relevant in the susceptibility to or the severity of 
      Japanese MS patients.
FAU - Niino, M
AU  - Niino M
AD  - Department of Neurology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan. niino@med.hokudai.ac.jp
FAU - Kikuchi, S
AU  - Kikuchi S
FAU - Fukazawa, T
AU  - Fukazawa T
FAU - Yabe, I
AU  - Yabe I
FAU - Sasaki, H
AU  - Sasaki H
FAU - Tashiro, K
AU  - Tashiro K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HSP70 Heat-Shock Proteins)
SB  - IM
MH  - Adult
MH  - Female
MH  - Genotype
MH  - HSP70 Heat-Shock Proteins/*genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - Multiple Sclerosis/*genetics
MH  - *Polymorphism, Genetic
EDAT- 2001/11/07 10:00
MHDA- 2002/02/15 10:01
CRDT- 2001/11/07 10:00
PHST- 2001/11/07 10:00 [pubmed]
PHST- 2002/02/15 10:01 [medline]
PHST- 2001/11/07 10:00 [entrez]
AID - 580205 [pii]
AID - 10.1034/j.1399-0039.2001.580205.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2001 Aug;58(2):93-6. doi: 10.1034/j.1399-0039.2001.580205.x.