PMID- 11696854
OWN - NLM
STAT- MEDLINE
DCOM- 20020617
LR  - 20190607
IS  - 0036-4665 (Print)
IS  - 0036-4665 (Linking)
VI  - 43
IP  - 5
DP  - 2001 Sep-Oct
TI  - Importance of immunoglobulin E (IgE) in the protective mechanism against 
      gastrointestinal nematode infection: looking at the intestinal mucosae.
PG  - 291-9
AB  - This review discusses experimental evidences that indicate the IgE participation 
      on the effector mechanisms that leads to gastrointestinal nematode elimination. 
      Data discussed here showed that, for most experimental models, the immune 
      response involved in nematode elimination is regulated by Th-2 type cytokines 
      (especially IL-4). However, the mechanism(s) that result in worm elimination is 
      not clear and might be distinct in different nematode species. Parasite specific 
      IgE production, especially the IgE produced by the intestinal mucosae or 
      associated lymphoid organs could participate in the intestinal elimination of 
      Trichinella spiralis from infected rats. Intestinal IgE may also be important to 
      the protective mechanism developed against other gastrointestinal nematodes that 
      penetrate the murine duodenum mucosa tissue, such as Strongyloides venezuelensis 
      and Heligmosomoides polygyrus. At least in Trichinella spiralis infected rats, 
      the results indicated that intestinal IgE might work independently from mast cell 
      degranulation for worm elimination.
FAU - Negrao-Correa, D
AU  - Negrao-Correa D
AD  - Department of Parasitology, Federal University of Minas Gerais, Belo Horizonte, 
      MG, Brazil. denegrao@icb.ufmg.br
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Brazil
TA  - Rev Inst Med Trop Sao Paulo
JT  - Revista do Instituto de Medicina Tropical de Sao Paulo
JID - 7507484
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Gastrointestinal Diseases/immunology/*parasitology
MH  - Immunity, Mucosal/immunology
MH  - Immunoglobulin E/biosynthesis/immunology/*physiology
MH  - Intestinal Mucosa/immunology/parasitology
MH  - Nematode Infections/*immunology
MH  - Rats
RF  - 101
EDAT- 2001/11/07 10:00
MHDA- 2002/06/18 10:01
CRDT- 2001/11/07 10:00
PHST- 2001/11/07 10:00 [pubmed]
PHST- 2002/06/18 10:01 [medline]
PHST- 2001/11/07 10:00 [entrez]
AID - S0036-46652001000500011 [pii]
AID - 10.1590/s0036-46652001000500011 [doi]
PST - ppublish
SO  - Rev Inst Med Trop Sao Paulo. 2001 Sep-Oct;43(5):291-9. doi: 
      10.1590/s0036-46652001000500011.