PMID- 11697509
OWN - NLM
STAT- MEDLINE
DCOM- 20020917
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 42
IP  - 4
DP  - 2001 Aug
TI  - Richter's syndrome following cladribine therapy for chronic lymphocytic leukemia 
      first manifested as pathologic fracture of the femur.
PG  - 789-96
AB  - Richter's syndrome (RS) refers to the development of aggressive non-Hodgkin's 
      lymphoma (NHL) during the course of chronic lymphocytic leukaemia (CCL). It 
      occurs in approximately 3% of patients with CLL. The isolated form of this 
      complication in bone is extremely rare and, so far, has not been described in a 
      patient treated with cladribine (2-CdA). We report a case of CLL treated 
      successfully with 2-CdA, where isolated diffuse large B-cell lymphoma (LBCL) 
      developed 2 years after the diagnosis of CLL Rai II and one year after the 
      completion of 2-CdA treatment. RS was first manifested as a pathologic fracture 
      of the left femur. The LBCL was clonally distinct from the original CLL cells. 
      The patient was successfully treated with CHOP and radiotherapy and obtained 
      complete response of the LBCL.
FAU - Robak, T
AU  - Robak T
AD  - Department of Hematology, Medical University of Lodz, Poland. 
      robaktad@psk2.am.lodz.pl
FAU - Kasznicki, M
AU  - Kasznicki M
FAU - Bartkowiak, J
AU  - Bartkowiak J
FAU - Kordek, R
AU  - Kordek R
FAU - Wawrzyniak, E
AU  - Wawrzyniak E
FAU - Blonski, J Z
AU  - Blonski JZ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 47M74X9YT5 (Cladribine)
SB  - IM
MH  - Aged
MH  - Bone Marrow/pathology
MH  - Cell Transformation, Neoplastic/chemically induced
MH  - Cladribine/administration & dosage/*adverse effects
MH  - Femoral Fractures/diagnostic imaging/*etiology
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*pathology
MH  - Lymph Nodes/pathology
MH  - Lymphoma, B-Cell/*pathology
MH  - Lymphoma, Non-Hodgkin/*chemically induced/etiology/pathology
MH  - Male
MH  - Neoplasms, Second Primary/chemically induced/etiology/pathology
MH  - Radionuclide Imaging
MH  - Syndrome
EDAT- 2001/11/08 10:00
MHDA- 2002/09/18 10:01
CRDT- 2001/11/08 10:00
PHST- 2001/11/08 10:00 [pubmed]
PHST- 2002/09/18 10:01 [medline]
PHST- 2001/11/08 10:00 [entrez]
AID - 10.3109/10428190109099341 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2001 Aug;42(4):789-96. doi: 10.3109/10428190109099341.