PMID- 11697581
OWN - NLM
STAT- MEDLINE
DCOM- 20020206
LR  - 20191105
IS  - 0940-1334 (Print)
IS  - 0940-1334 (Linking)
VI  - 251
IP  - 4
DP  - 2001 Aug
TI  - Hypoxia and hypoxia-inducible factor modulated gene expression in brain: 
      involvement in neuroprotection and cell death.
PG  - 170-8
AB  - Hypoxia, due to impaired cerebral blood flow, has hazardous effects on brain 
      structure and function. Therefore, mechanisms should exist to meet the needs for 
      hypoxic adaptation via regulation of gene expression. Signaling between the O2 
      sensor and the regulator(s) of transcription is only partially characterized and 
      requires regulatory transcription factors. Among these regulatory proteins, 
      hypoxia-inducible factor-1 (HIF-1) appears to have a key role. HIF-1 modulates 
      gene activity in response to low O2 tensions in the developing and in the adult 
      brain. Moderate hypoxia may elicit autoprotective mechanisms or hypoxia-induced 
      regulators can contribute to mechanisms leading to cell death. Moreover, 
      reactivation of embryonic gene expression may occur after injury-induced hypoxia. 
      Thus, analyses of embryonic and pathogenic models should help to understand how 
      hypoxia-mediated proliferative/cell death processes are involved in brain 
      development and in the pathogenesis of acute or chronic neurodegenerative brain 
      diseases.
FAU - Kietzmann, T
AU  - Kietzmann T
AD  - Institut fur Biochemie und Molekulare Zellbiologie, Gottingen, Germany. 
      tkietzm@gwdg.de
FAU - Knabe, W
AU  - Knabe W
FAU - Schmidt-Kastner, R
AU  - Schmidt-Kastner R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adaptation, Physiological
MH  - Adult
MH  - Animals
MH  - Apoptosis
MH  - Brain/embryology/*metabolism/physiopathology
MH  - Cell Death
MH  - DNA-Binding Proteins/*metabolism
MH  - Gene Expression Regulation
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Hypoxia/metabolism/*physiopathology
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Neurons/metabolism
MH  - Nuclear Proteins/*metabolism
MH  - Signal Transduction
MH  - Transcription Factors/*metabolism
RF  - 94
EDAT- 2001/11/08 10:00
MHDA- 2002/02/07 10:01
CRDT- 2001/11/08 10:00
PHST- 2001/11/08 10:00 [pubmed]
PHST- 2002/02/07 10:01 [medline]
PHST- 2001/11/08 10:00 [entrez]
AID - 10.1007/s004060170037 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2001 Aug;251(4):170-8. doi: 
      10.1007/s004060170037.