PMID- 11697937
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20071114
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 14
IP  - 5
DP  - 2001 Nov
TI  - Validating cortical surface analysis of medial prefrontal cortex.
PG  - 1058-69
AB  - This paper describes cortical analysis of 19 high resolution MRI subvolumes of 
      medial prefrontal cortex (MPFC), a region that has been implicated in major 
      depressive disorder. An automated Bayesian segmentation is used to delineate the 
      MRI subvolumes into cerebrospinal fluid (CSF), gray matter (GM), white matter 
      (WM), and partial volumes of either CSF/GM or GM/WM. The intensity value at which 
      there is equal probability of GM and GM/WM partial volume is used to reconstruct 
      MPFC cortical surfaces based on a 3-D isocontouring algorithm. The segmented data 
      and the generated surfaces are validated by comparison with hand segmented data 
      and semiautomated contours, respectively. The L(1) distances between Bayesian and 
      hand segmented data are 0.05-0.10 (n = 5). Fifty percent of the voxels of the 
      reconstructed surface lie within 0.12-0.28 mm (n = 14) from the semiautomated 
      contours. Cortical thickness metrics are generated in the form of frequency of 
      occurrence histograms for GM and WM labelled voxels as a function of their 
      position from the cortical surface. An algorithm to compute the surface area of 
      the GM/WM interface of the MPFC subvolume is described. These methods represent a 
      novel approach to morphometric chacterization of regional cortex features which 
      may be important in the study of psychiatric disorders such as major depression.
CI  - Copyright 2001 Academic Press.
FAU - Ratnanather, J T
AU  - Ratnanather JT
AD  - Center for Imaging Science, The Johns Hopkins University, Baltimore, Maryland 
      21218-2686, USA.
FAU - Botteron, K N
AU  - Botteron KN
FAU - Nishino, T
AU  - Nishino T
FAU - Massie, A B
AU  - Massie AB
FAU - Lal, R M
AU  - Lal RM
FAU - Patel, S G
AU  - Patel SG
FAU - Peddi, S
AU  - Peddi S
FAU - Todd, R D
AU  - Todd RD
FAU - Miller, M I
AU  - Miller MI
LA  - eng
GR  - 5-R01-NS35368-05/NS/NINDS NIH HHS/United States
GR  - K08-MH01292/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Twin Study
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Bayes Theorem
MH  - Cephalometry
MH  - Cerebrospinal Fluid/physiology
MH  - Depressive Disorder, Major/*pathology
MH  - Female
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - *Imaging, Three-Dimensional
MH  - *Magnetic Resonance Imaging
MH  - Prefrontal Cortex/*pathology
MH  - Reference Values
MH  - Sensitivity and Specificity
EDAT- 2001/11/08 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/08 10:00
PHST- 2001/11/08 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/08 10:00 [entrez]
AID - S1053-8119(01)90906-1 [pii]
AID - 10.1006/nimg.2001.0906 [doi]
PST - ppublish
SO  - Neuroimage. 2001 Nov;14(5):1058-69. doi: 10.1006/nimg.2001.0906.