PMID- 11698285
OWN - NLM
STAT- MEDLINE
DCOM- 20011221
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 98
IP  - 10
DP  - 2001 Nov 15
TI  - Reduced blood CD123+ (lymphoid) and CD11c+ (myeloid) dendritic cell numbers in 
      primary HIV-1 infection.
PG  - 3016-21
AB  - Successful immunologic control of HIV infection is achieved only in rare 
      individuals. Dendritic cells (DCs) are required for specific antigen presentation 
      to naive T lymphocytes and for antiviral, type I interferon secretion. Two major 
      blood DC populations are found: CD11c+ (myeloid) DCs, which secrete IL-12, and 
      CD123+ (IL-3-receptor+) DCs (lymphoid), which secrete type I interferons in 
      response to viral stimuli. The authors have previously found a decreased 
      proportion of blood CD11c+ DCs in chronic HIV+ patients. In this study, 26 to 57 
      days after infection and before treatment, CD123+ and CD11c+ DC numbers were 
      dramatically reduced in 13 HIV+ patients compared with 13 controls (P =.0002 and 
      P =.001, respectively). After 6 to 12 months of highly active antiretroviral 
      therapy, DC subpopulation average numbers remained low, but CD123+ DC numbers 
      increased again in 5 of 13 patients. A strong correlation was found between this 
      increase and CD4 T-cell count increase (P =.0009) and plasma viral load decrease 
      (P =.009). Reduced DC numbers may participate in the functional impairment of 
      HIV-specific CD4+ T cells and be responsible for the low type I interferon 
      responsiveness already known in HIV infection. The restoration of DC numbers may 
      be predictive of immune restoration and may be a goal for immunotherapy to 
      enhance viral control in a larger proportion of patients.
FAU - Pacanowski, J
AU  - Pacanowski J
AD  - Unite INSERM 445, Immunologie des pathologies infectieuses et tumorales, 
      Departement d'Immunologie, Institut Cochin de Genetique Moleculaire and 
      Laboratoire de Virologie, Hopital St-Vincent de Paul, Paris, France.
FAU - Kahi, S
AU  - Kahi S
FAU - Baillet, M
AU  - Baillet M
FAU - Lebon, P
AU  - Lebon P
FAU - Deveau, C
AU  - Deveau C
FAU - Goujard, C
AU  - Goujard C
FAU - Meyer, L
AU  - Meyer L
FAU - Oksenhendler, E
AU  - Oksenhendler E
FAU - Sinet, M
AU  - Sinet M
FAU - Hosmalin, A
AU  - Hosmalin A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (IL3RA protein, human)
RN  - 0 (Integrin alphaXbeta2)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukin-3 Receptor alpha Subunit)
RN  - 0 (RNA, Viral)
RN  - 0 (Receptors, Interleukin-3)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - Blood Cell Count
MH  - CD4 Lymphocyte Count
MH  - Dendritic Cells/metabolism/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/*blood/drug therapy/immunology
MH  - HIV-1
MH  - Humans
MH  - Integrin alphaXbeta2/*analysis
MH  - Interferon-alpha/blood/deficiency/metabolism
MH  - Interleukin-12/metabolism
MH  - Interleukin-3 Receptor alpha Subunit
MH  - Lymphocytes/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Myeloid Cells/metabolism/pathology
MH  - RNA, Viral/blood
MH  - Receptors, Interleukin-3/*analysis
MH  - Viral Load
EDAT- 2001/11/08 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/08 10:00
PHST- 2001/11/08 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/08 10:00 [entrez]
AID - S0006-4971(20)56835-3 [pii]
AID - 10.1182/blood.v98.10.3016 [doi]
PST - ppublish
SO  - Blood. 2001 Nov 15;98(10):3016-21. doi: 10.1182/blood.v98.10.3016.