PMID- 11699201
OWN - NLM
STAT- MEDLINE
DCOM- 20020516
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 42
IP  - 1-2
DP  - 2001 Jun
TI  - Adult T-cell leukemia/lymphoma and cluster of HTLV-I associated diseases in 
      Brazilian settings.
PG  - 135-44
AB  - We studied the transmission routes of human T-cell lymphotropic virus type I 
      (HTLV-I) within families of 82 Brazilian patients diagnosed with adult T-cell 
      leukaemia/lymphoma (ATL). Diagnosis of ATL in 43 male and 39 female patients was 
      based on clinical and laboratory criteria of T-cell malignancy and detection of 
      HTLV-I monoclonal integration. Samples were tested for HTLV antibodies and 
      infection was confirmed as HTLV-I by Western Blot and/or polymerase chain 
      reaction (PCR) assays. Overall 26/37 (70%) of mothers, 24/37 (65%) of wives, 8/22 
      (36%) of husbands, 34/112 (30%) of siblings and 10/82 (12%) offspring were HTLV-I 
      infected. In 11 ATL patients, mothers were repeatedly HTLV-I seronegative, but 
      HTLV-I pol or tax sequences were detected in 2 out of 6 cases tested by PCR. ATL 
      patients with seronegative mothers related the following risk factors for HTLV-I 
      infection: 6 were breast-fed by surrogate mothers with unknown HTLV-I status, 4 
      had a sexually promiscuous behaviour and 1 had multiple blood transfusions at a 
      young age. Familial aggregation of ATL and other HTLV-I associated diseases such 
      as HTLV-I myelopathy (HAM/TSP) and or uveitis, ATL in sibling pairs or in 
      multiple generations was seen in 9 families. There were 6 families with ATL and 
      TSP sibling pairs. In 3 families at least one parent had died with lymphoma or 
      presenting neurological diseases and 2 offspring with ATL. Further to the extent 
      of vertical and horizontal transmission of HTLV-I infection within ATL families, 
      our results demonstrate that mothers who provide surrogate breast-milk appear to 
      be an important source of HTLV-I transmission and ATL development in Brazil.
FAU - Pombo-de-Oliveira, M S
AU  - Pombo-de-Oliveira MS
AD  - Cell Marker Laboratory-Department of Hematology of Instituto Nacional de Cancer, 
      Hematologia Clinica, Praca Cruz Vermelha, 23, 7th floor, CEP 20 230 030-Rio de 
      Janeiro, Brazil. mpombo@inca.org.br
FAU - Carvalho, S M
AU  - Carvalho SM
FAU - Borducchi, D
AU  - Borducchi D
FAU - Dobbin, J
AU  - Dobbin J
FAU - Salvador, J
AU  - Salvador J
FAU - Correa, R B
AU  - Correa RB
FAU - Moellman, A
AU  - Moellman A
FAU - Loureiro, P
AU  - Loureiro P
FAU - Chiattone, C
AU  - Chiattone C
FAU - Rios, M
AU  - Rios M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Brazil/epidemiology
MH  - Breast Feeding/adverse effects
MH  - Disease Transmission, Infectious/statistics & numerical data
MH  - Family Health
MH  - Female
MH  - HTLV-I Infections/diagnosis/epidemiology/*transmission
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/statistics & numerical data
MH  - Leukemia-Lymphoma, Adult T-Cell
MH  - Male
MH  - Nuclear Family
MH  - Paraparesis, Tropical Spastic
MH  - Pedigree
EDAT- 2001/11/09 10:00
MHDA- 2002/05/17 10:01
CRDT- 2001/11/09 10:00
PHST- 2001/11/09 10:00 [pubmed]
PHST- 2002/05/17 10:01 [medline]
PHST- 2001/11/09 10:00 [entrez]
AID - 10.3109/10428190109097685 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2001 Jun;42(1-2):135-44. doi: 10.3109/10428190109097685.