PMID- 11700807
OWN - NLM
STAT- MEDLINE
DCOM- 20020508
LR  - 20190815
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 22
IP  - 24
DP  - 2001 Dec
TI  - Retinal pigment epithelium engineering using synthetic biodegradable polymers.
PG  - 3345-55
AB  - Retinal pigment epithelium (RPE) plays a key role in the maintenance of the 
      normal functions of the retina, especially photoreceptors. Alteration in RPE 
      structure and function is implicated in a variety of ocular disorders. Tissue 
      engineering strategies using synthetic biodegradable polymers as temporary 
      substrates for RPE cell culture and subsequent transplantation may provide a 
      promising new therapy. In this review article, the manufacture of thin 
      biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) films and their degradation 
      behavior in vitro are discussed. RPE cell proliferation and differentiation on 
      these PLGA films are reviewed. The fabrication of model substrates with desired 
      chemical micropatterns in the micrometer scale is discussed and the effects of 
      surface patterning on RPE morphology and function are assessed. Finally. the 
      preparation of biodegradable micropatterns with adhesive PLGA and non-adhesive 
      poly(ethylene glycol)/PLA domains to modulate RPE cell adhesion is presented.
FAU - Lu, L
AU  - Lu L
AD  - Department of Orthopedic Surgery and Bioengineering, Mayo Clinic, Rochester, MN 
      55905, USA.
FAU - Yaszemski, M J
AU  - Yaszemski MJ
FAU - Mikos, A G
AU  - Mikos AG
LA  - eng
GR  - R29-AR42639/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - *Biocompatible Materials
MH  - Cell Adhesion
MH  - Cell Culture Techniques/methods
MH  - Cell Division
MH  - Humans
MH  - Lactic Acid
MH  - Materials Testing
MH  - Pigment Epithelium of Eye/*cytology/*transplantation
MH  - Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers
MH  - Retinal Diseases/surgery
MH  - Surface Properties
MH  - Tissue Engineering/*methods
RF  - 69
OTO - NASA
OT  - Non-programmatic
EDAT- 2001/11/10 10:00
MHDA- 2002/05/09 10:01
CRDT- 2001/11/10 10:00
PHST- 2001/11/10 10:00 [pubmed]
PHST- 2002/05/09 10:01 [medline]
PHST- 2001/11/10 10:00 [entrez]
AID - S0142-9612(01)00172-7 [pii]
AID - 10.1016/s0142-9612(01)00172-7 [doi]
PST - ppublish
SO  - Biomaterials. 2001 Dec;22(24):3345-55. doi: 10.1016/s0142-9612(01)00172-7.