PMID- 11701134
OWN - NLM
STAT- MEDLINE
DCOM- 20020115
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 919
IP  - 2
DP  - 2001 Nov 23
TI  - Regional haemodynamic responses to activation of the medial prefrontal cortex 
      depressor region.
PG  - 221-31
AB  - Electrical or chemical stimulation of the medial prefrontal cortex (MPFC) 
      produces depressor and sympathoinhibitory responses. To characterise the MPFC 
      depressor response more fully, we determined the regional haemodynamic changes 
      which occurred in response to stimulation of the MPFC. In halothane-anaesthetised 
      rats, we recorded arterial blood pressure and renal, superior mesenteric, and 
      iliac arterial vascular conductance using miniaturised Doppler flow probes. 
      Electrical stimulation of the MPFC (50-100 microA) was used to map the location 
      of the depressor region. Increases in vascular conductance (or increases in blood 
      flow) were recorded from the renal (+2.3+/-0.5 kHz/mmHgx10(3)), mesenteric 
      (+4.4+/-0.4 kHz/mmHgx10(3)), and iliac (+8.3+/-1.0 kHz/mmHgx10(3)) vascular beds 
      in response to stimulation of the MPFC depressor region coinciding with the 
      ventral infralimbic (IL) and dorsal peduncular (DP) cortical areas. Similar 
      responses were obtained after microinjection of the chemical excitant L-glutamate 
      (n=3, 100 nl, 100 mM), indicating that the responses were due to excitation of 
      cell bodies and not due to axons traversing the area. Administration of the 
      nitric oxide synthesis inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 25 
      micromol/kg, i.v., n=5) significantly reduced the MPFC depressor response (51%, 
      12.5+/-1.2 to 6.1+/-2.5 mmHg). The increases in conductance in the hindquarter 
      and mesenteric vascular beds were significantly reduced after L-NAME treatment 
      (mesenteric by 77%, iliac by 70%), but there was no significant reduction of 
      renal flow (35%). These observations indicate that the depressor region of the 
      MPFC is localised to ventral regions (IL and DP) and that the depressor response 
      is mediated by increased conductance in the hindquarters and mesenteric vascular 
      beds. Furthermore, the depressor response may be mediated, in part, by release of 
      nitric oxide in these vascular beds.
FAU - Owens, N C
AU  - Owens NC
AD  - Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin and 
      Repatriation Medical Centre, University of Melbourne, Heidelberg, Victoria, 
      Australia.
FAU - Verberne, A J
AU  - Verberne AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Enzyme Inhibitors)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects/*physiology
MH  - Efferent Pathways/drug effects/*physiology
MH  - Electric Stimulation
MH  - Enzyme Inhibitors/pharmacology
MH  - Glutamic Acid/metabolism/pharmacology
MH  - Iliac Artery/drug effects/physiology
MH  - Male
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Neural Inhibition/drug effects/physiology
MH  - Nitric Oxide/*metabolism
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reflex/drug effects/physiology
MH  - Regional Blood Flow/drug effects/*physiology
MH  - Splanchnic Circulation/drug effects/physiology
MH  - Sympathetic Nervous System/drug effects/*physiology
MH  - Vasodilation/drug effects/*physiology
EDAT- 2001/11/10 10:00
MHDA- 2002/01/16 10:01
CRDT- 2001/11/10 10:00
PHST- 2001/11/10 10:00 [pubmed]
PHST- 2002/01/16 10:01 [medline]
PHST- 2001/11/10 10:00 [entrez]
AID - S0006-8993(01)03017-7 [pii]
AID - 10.1016/s0006-8993(01)03017-7 [doi]
PST - ppublish
SO  - Brain Res. 2001 Nov 23;919(2):221-31. doi: 10.1016/s0006-8993(01)03017-7.