PMID- 11701697
OWN - NLM
STAT- MEDLINE
DCOM- 20011213
LR  - 20061115
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 86
IP  - 11
DP  - 2001 Nov
TI  - Increased risk for nonmedullary thyroid cancer in the first degree relatives of 
      prevalent cases of nonmedullary thyroid cancer: a hospital-based study.
PG  - 5307-12
AB  - The genetic basis for nonmedullary forms of thyroid cancer (NMTC) is less well 
      established than that of medullary thyroid cancer. However, epidemiological and 
      family studies suggest that a proportion of NMTC may be due to inherited 
      predisposition. To estimate the familial risk of thyroid cancer, we conducted a 
      hospital-based case-control study at the Princess Margaret Hospital in Toronto, 
      Ontario, Canada, and at 2 university hospitals in Montreal, Quebec, Canada. We 
      obtained pedigrees from 339 unselected patients diagnosed with NMTC and from 319 
      unaffected ethnically matched controls. Family histories of cancer were obtained 
      from the cases and controls for 3292 first degree relatives of cases and 
      controls. Seventeen cases (5.0%) and 2 controls (0.6%) reported at least one 
      first degree relative with thyroid cancer. In relatives of patients with thyroid 
      cancer, the incidence of any type of cancer (including NMTC) was 38% higher than 
      in relatives of controls (incidence rate ratio, 1.4; 95% confidence interval, 
      1.1-1.7). The relative risk for thyroid cancer was 10-fold higher in relatives of 
      cancer patients than in controls (incidence rate ratio, 10.3; 95% confidence 
      interval, 2.2-47.6). Our findings suggest that hereditary or other familial 
      factors are important in a small proportion of NMTC. Molecular studies are needed 
      to determine the genetic basis of cancer susceptibility in these families.
FAU - Pal, T
AU  - Pal T
AD  - Center for Research in Women's Health, Sunnybrook and Women's College Health 
      Sciences Center, Toronto, Ontario, Canada M5G 1N8.
FAU - Vogl, F D
AU  - Vogl FD
FAU - Chappuis, P O
AU  - Chappuis PO
FAU - Tsang, R
AU  - Tsang R
FAU - Brierley, J
AU  - Brierley J
FAU - Renard, H
AU  - Renard H
FAU - Sanders, K
AU  - Sanders K
FAU - Kantemiroff, T
AU  - Kantemiroff T
FAU - Bagha, S
AU  - Bagha S
FAU - Goldgar, D E
AU  - Goldgar DE
FAU - Narod, S A
AU  - Narod SA
FAU - Foulkes, W D
AU  - Foulkes WD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - Pedigree
MH  - Quebec/epidemiology
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Thyroid Neoplasms/epidemiology/*genetics
EDAT- 2001/11/10 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/10 10:00
PHST- 2001/11/10 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/10 10:00 [entrez]
AID - 10.1210/jcem.86.11.8010 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2001 Nov;86(11):5307-12. doi: 10.1210/jcem.86.11.8010.