PMID- 11702485
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20220316
IS  - 0008-4263 (Print)
IS  - 1920-7476 (Electronic)
IS  - 0008-4263 (Linking)
VI  - 92
IP  - 5
DP  - 2001 Sep-Oct
TI  - From "thrifty genotype" to "hefty fetal phenotype": the relationship between high 
      birthweight and diabetes in Saskatchewan Registered Indians.
PG  - 340-4
AB  - BACKGROUND: Intrauterine factors have been implicated in the pathogenesis of Type 
      2 diabetes mellitus (T2DM). METHODS: In a 1:1 matched pairs case-control study, 
      high and low birthweight (HBW, LBW) rates in Saskatchewan Registered Indian (RI) 
      diabetic cases were compared with corresponding rates in RI without diabetes, and 
      non-RI people with and without diabetes. RESULTS: Birthweights were available for 
      73% of the 1,366 cases and 3 x 1,366 controls. A greater proportion of RI 
      diabetics were born with HBW (> 4000 grams) compared to RI non-diabetics (16.2% 
      vs 10.7%; p < 0.01). There was a significant association between HBW (but not LBW 
      [< 2500 grams]) and diabetes for RI people (OR 1.63 [95% CI 1.20, 2.24]), which 
      was stronger for RI females and strengthened progressively from mid to late 20th 
      century. INTERPRETATION: Certain causes of HBW may predispose to subsequent 
      development of T2DM in Canadian Aboriginal people ("hefty fetal phenotype" 
      ["hefty fetal type"] hypothesis). Programs that optimize healthy pregnancies 
      could reduce T2DM incidence in future generations.
FAU - Dyck, R F
AU  - Dyck RF
AD  - College of Medicine, University of Saskatchewan, Saskatoon, SK. 
      dyck@sask.usask.ca
FAU - Klomp, H
AU  - Klomp H
FAU - Tan, L
AU  - Tan L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Birth Weight
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Child
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*ethnology/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Indians, North American/*genetics
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Matched-Pair Analysis
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Phenotype
MH  - Pregnancy
MH  - Pregnancy in Diabetics/*ethnology/*genetics
MH  - Registries
MH  - Saskatchewan/epidemiology
MH  - Sex Distribution
PMC - PMC6979700
EDAT- 2001/11/13 10:00
MHDA- 2002/01/05 10:01
PMCR- 2002/09/01
CRDT- 2001/11/13 10:00
PHST- 2001/11/13 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/13 10:00 [entrez]
PHST- 2002/09/01 00:00 [pmc-release]
AID - BF03404975 [pii]
AID - 10.1007/BF03404975 [doi]
PST - ppublish
SO  - Can J Public Health. 2001 Sep-Oct;92(5):340-4. doi: 10.1007/BF03404975.