PMID- 11703412
OWN - NLM
STAT- MEDLINE
DCOM- 20020821
LR  - 20190921
IS  - 0141-9854 (Print)
IS  - 0141-9854 (Linking)
VI  - 23
IP  - 5
DP  - 2001 Oct
TI  - The outcome of ambulatory DVT management using a multidisciplinary approach.
PG  - 301-6
AB  - Low molecular weight heparins (LMWHs) have been demonstrated to be at least as 
      safe and effective as unfractionated heparin (UFH) in the initial management of 
      deep vein thrombosis (DVT). However, the effectiveness of using LMWH in the 
      ambulatory management of DVT in a 'real-life' setting has yet to be evaluated. 
      This multicentre retrospective study involving 697 patients considers the outcome 
      data of patients under- going ambulatory DVT treatment with tinzaparin 
      (Innohep(R), Leo Pharmaceuticals, Risborough, Buckinghamshire, UK). During the 6 
      months following presentation, 17 (2.5%) patients had confirmed thromboembolic 
      complications, of which 14 occurred subsequent to the initial LMWH treatment 
      phase ('late'). There were no deaths in this group. Bleeding complications were 
      reported in 23 (3.4%) patients, with 13 of these being classified as 'late'. Of 
      these, two events were considered major resulting in hospitalization and death. 
      Hospitalization for all causes was 6.8% (45 patients) with 32 patients being 
      admitted for thromboembolic or bleeding complications. Overall mortality was 
      6.7%. These results compare favourably with published clinical trial data. This 
      study demonstrates that ambulatory treatment of proven DVT with LMWH is both safe 
      and effective.
FAU - Rose, P
AU  - Rose P
AD  - South Warwickshire NHS Trust, Warwick, UK. peter.rose@swarkhosp-tr.wmids.nhs.uk
FAU - Bell, D
AU  - Bell D
FAU - Green, E S
AU  - Green ES
FAU - Davenport, A
AU  - Davenport A
FAU - Fegan, C
AU  - Fegan C
FAU - Grech, H
AU  - Grech H
FAU - O'Shaughnessy, D
AU  - O'Shaughnessy D
FAU - Voke, J
AU  - Voke J
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Lab Haematol
JT  - Clinical and laboratory haematology
JID - 7907061
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 7UQ7X4Y489 (Tinzaparin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Ambulatory Care/methods/*standards
MH  - Disease Management
MH  - Drug Evaluation
MH  - Female
MH  - Fibrinolytic Agents/administration & dosage/standards/toxicity
MH  - Hemorrhage/chemically induced
MH  - Heparin, Low-Molecular-Weight/administration & dosage/standards/toxicity
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Thromboembolism/etiology
MH  - Tinzaparin
MH  - Treatment Outcome
MH  - Venous Thrombosis/complications/*drug therapy/mortality
EDAT- 2001/11/13 10:00
MHDA- 2002/08/22 10:01
CRDT- 2001/11/13 10:00
PHST- 2001/11/13 10:00 [pubmed]
PHST- 2002/08/22 10:01 [medline]
PHST- 2001/11/13 10:00 [entrez]
AID - 403 [pii]
AID - 10.1046/j.1365-2257.2001.00403.x [doi]
PST - ppublish
SO  - Clin Lab Haematol. 2001 Oct;23(5):301-6. doi: 10.1046/j.1365-2257.2001.00403.x.