PMID- 11703451 OWN - NLM STAT- MEDLINE DCOM- 20011218 LR - 20190815 IS - 0953-816X (Print) IS - 0953-816X (Linking) VI - 14 IP - 8 DP - 2001 Oct TI - Brain-derived neurotrophic factor induces long-lasting potentiation of synaptic transmission in visual cortex in vivo in young rats, but not in the adult. PG - 1219-28 AB - Brain-derived neurotrophic factor (BDNF) rapidly enhances excitatory synaptic transmission in cortical slices. To date, however, a question of how long such an action persists remains unanswered as it is hard to record synaptic responses longer than several hours in slice preparations. To address this question and to investigate possible age-dependency of the action, we analysed effects of a brief application of BDNF and nerve growth factor (NGF) on field potentials of visual cortex in rats of postnatal days 13-17 and 19-24 and in the adulthood for 10-24 h. Evoked potentials to stimulation of the lateral geniculate nucleus were recorded simultaneously from two cortical sites into which the neurotrophin and control solution were injected. An application of BDNF induced a slowly developing increase in the field potential amplitude in young rats. The amplitude attained a plateau level 3-4 h after the infusion; 139 +/- 26% (mean +/- SD) and 132 +/- 21% of the baseline in the rats at P13-17 and P19-24, respectively. This potentiation remained stable from 4 to 8 h, then gradually decreased to the baseline 15-16 h after the infusion. NGF applied in the same way did not induce potentiation. An inhibitor of BDNF receptors blocked the potentiation when it was applied immediately after the BDNF application, but was not effective about 2 h later. In the adults, BDNF did not potentiate field potentials. These results indicate that BDNF induces synaptic potentiation lasting for several hours only in the developing cortex through processes downstream of receptor activation. FAU - Jiang, B AU - Jiang B AD - Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012 Japan. FAU - Akaneya, Y AU - Akaneya Y FAU - Ohshima, M AU - Ohshima M FAU - Ichisaka, S AU - Ichisaka S FAU - Hata, Y AU - Hata Y FAU - Tsumoto, T AU - Tsumoto T LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - France TA - Eur J Neurosci JT - The European journal of neuroscience JID - 8918110 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Carbazoles) RN - 0 (Enzyme Inhibitors) RN - 0 (Excitatory Amino Acid Antagonists) RN - 0 (Indole Alkaloids) RN - 0 (Receptors, Glutamate) RN - 97161-97-2 (staurosporine aglycone) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Aging/*physiology MH - Animals MH - Animals, Newborn/anatomy & histology/growth & development/metabolism MH - Brain-Derived Neurotrophic Factor/metabolism/*pharmacology MH - Carbazoles/pharmacology MH - Electric Stimulation MH - Enzyme Inhibitors/pharmacology MH - Excitatory Amino Acid Antagonists/pharmacology MH - Excitatory Postsynaptic Potentials/drug effects/physiology MH - Geniculate Bodies/physiology MH - Immunohistochemistry MH - Indole Alkaloids MH - Long-Term Potentiation/*drug effects/physiology MH - Membrane Potentials/drug effects/physiology MH - Neurons/*drug effects/metabolism MH - Organ Culture Techniques MH - Rats MH - Reaction Time/drug effects/physiology MH - Receptor, trkB/agonists/antagonists & inhibitors/metabolism MH - Receptors, Glutamate/drug effects/metabolism MH - Synaptic Transmission/*drug effects/physiology MH - Visual Cortex/*drug effects/*growth & development/metabolism EDAT- 2001/11/13 10:00 MHDA- 2002/01/05 10:01 CRDT- 2001/11/13 10:00 PHST- 2001/11/13 10:00 [pubmed] PHST- 2002/01/05 10:01 [medline] PHST- 2001/11/13 10:00 [entrez] AID - 1751 [pii] AID - 10.1046/j.0953-816x.2001.01751.x [doi] PST - ppublish SO - Eur J Neurosci. 2001 Oct;14(8):1219-28. doi: 10.1046/j.0953-816x.2001.01751.x.