PMID- 11704610
OWN - NLM
STAT- MEDLINE
DCOM- 20011221
LR  - 20220408
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 164
IP  - 8 Pt 2
DP  - 2001 Oct 15
TI  - The role of immunoglobulin E in allergy and asthma.
PG  - S1-5
AB  - It has been nearly a century since the first suggestion that a soluble factor in 
      plasma or serum might be responsible for the symptoms of allergic disease and 
      asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the 
      key molecule in mediating what are now described as type 1 hypersensitivity 
      reactions (allergic asthma, allergic rhinitis, food allergy, atopic dermatitis, 
      some forms of drug allergy, and insect sting allergy). Since that time, many of 
      the details of the inflammatory cascade underlying allergy and asthma have been 
      elucidated, and IgE is now known to play a key upstream role. The goals of this 
      report are to review the cellular and molecular events set in motion by IgE and 
      to examine the evidence for its participation in both the immediate allergic 
      response and the late-phase or chronic inflammatory response in the skin and 
      lungs.
FAU - Platts-Mills, T A
AU  - Platts-Mills TA
AD  - Division of Allergy and Immunology, University of Virginia, Charlottesville, 
      Virginia, USA. tap2z@virginia.edu
LA  - eng
GR  - AI-20565/AI/NIAID NIH HHS/United States
GR  - P01-AI50989/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/*immunology
RF  - 35
EDAT- 2001/11/13 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/13 10:00
PHST- 2001/11/13 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/13 10:00 [entrez]
AID - 10.1164/ajrccm.164.supplement_1.2103024 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 2):S1-5. doi: 
      10.1164/ajrccm.164.supplement_1.2103024.