PMID- 11705788
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20220311
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 281
IP  - 6
DP  - 2001 Dec
TI  - Progesterone does not alter osmotic regulation of AVP.
PG  - R2011-20
AB  - To test the hypothesis that progesterone, independent of estrogen, decreases the 
      plasma osmotic threshold for arginine vasopressin (AVP) release and thirst onset, 
      we compared AVP and thirst responses to hypertonic saline infusion (HSI) during 
      administration of oral contraceptives (OCs) containing progesterone (OCP) with 
      responses to infusion of OCs containing progesterone and estrogen (OCEP). Eight 
      women (29 +/- 2 yr) were infused with 3% NaCl (120 min, 0.1 ml. kg body wt(-1). 
      min(-1)) and consumed fluid (90 min, 15 ml/kg body wt) in the early follicular 
      and midluteal phases of a 28-day menstrual cycle and also after 4 wk of OCP and 
      after 4 wk of OCEP in a randomized crossover design. Baseline plasma osmolality 
      (P(osm)) was lower in the luteal phase (280 +/- 1 mosmol/kgH(2)O) and during OCEP 
      (283 +/- 1 mosmol/kgH(2)O) than in the follicular phase (286 +/- 1 
      mosmol/kgH(2)O, P < 0.05) but was unaffected by OCP (284 +/- 1 mosmol/kgH(2)O). 
      P(osm) remained lower in the follicular phase than in the luteal phase and with 
      OCEP throughout the first 50 min of HSI. The mean abscissal plasma AVP 
      concentration-P(osm) intercept was unaffected by OCP (267 +/- 1 mosmol/kgH(2)O) 
      but was greater in the follicular phase (273 +/- 2 mosmol/kgH(2)O) than in the 
      luteal phase (266 +/- 4 mosmol/kgH(2)O) and with OCEP (268 +/- 2 mosmol/kgH(2)O, 
      P < 0.05). There were no differences in osmotic thresholds for thirst onset 
      across experimental days. Despite the lower osmotic threshold for AVP release 
      during the luteal phase and with OCEP, fluid balance, renal free water clearance, 
      and Na(+) regulation during HSI were unaffected by menstrual phase or OC 
      treatment, indicating a lower osmotic operating point for body water balance. OCP 
      did not affect osmotic AVP regulation, suggesting that progesterone does not 
      affect osmotic fluid regulation through a mechanism independent of estrogen.
FAU - Calzone, W L
AU  - Calzone WL
AD  - The John B. Pierce Laboratory, Yale University School of Medicine, 290 Congress 
      Ave., New Haven, CT 06519, USA.
FAU - Silva, C
AU  - Silva C
FAU - Keefe, D L
AU  - Keefe DL
FAU - Stachenfeld, N S
AU  - Stachenfeld NS
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Arginine Vasopressin/*pharmacology
MH  - Blood Volume/drug effects
MH  - Estradiol/blood
MH  - Female
MH  - Follicular Phase/drug effects
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Luteal Phase/drug effects
MH  - Menstrual Cycle/drug effects/*physiology
MH  - Progesterone/blood/*pharmacology
MH  - Thirst/drug effects
MH  - Water-Electrolyte Balance/*drug effects
EDAT- 2001/11/14 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/14 10:00
PHST- 2001/11/14 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/14 10:00 [entrez]
AID - 10.1152/ajpregu.2001.281.6.R2011 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2001 Dec;281(6):R2011-20. doi: 
      10.1152/ajpregu.2001.281.6.R2011.