PMID- 11705916
OWN - NLM
STAT- MEDLINE
DCOM- 20011212
LR  - 20220316
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 69
IP  - 12
DP  - 2001 Dec
TI  - Mouse strain-dependent chemokine regulation of the genital tract T helper cell 
      type 1 immune response.
PG  - 7419-24
AB  - Vaginal infection with the mouse pneumonitis agent of Chlamydia trachomatis 
      (MoPn) produces shorter courses of infection in C57BL/6 and BALB/c mice than in 
      C3H/HeN mice, while C57BL/6 mice are more resistant to oviduct pathology. A 
      robust Th1 response is extremely important in host defense against chlamydia. In 
      this study we examined gamma interferon (IFN-gamma), interleukin 10 (IL-10), and 
      the T-cell-regulatory chemokines macrophage inflammatory protein-1alpha 
      (MIP-1alpha) and monocyte chemoattractant protein-1 (MCP-1) to determine if 
      differences in these responses were associated with the differential courses of 
      infection seen in these three strains of mice. Increased and prolonged IFN-gamma 
      responses and lower IL-10 responses were observed in the C57BL/6 strain compared 
      to BALB/c and C3H. Examination of genital tract chemokines revealed a marked 
      predominance of MIP-1alpha over MCP-1 only in the C57 strain. Thus, a pattern of 
      high MIP-1alpha and low MCP-1 levels during the first week of infection is 
      associated with an increased Th1 response and a shorter, more benign chlamydial 
      infection. Inhibition of the MCP-1 response in C3H mice increased their later 
      T-cell production of IFN-gamma but decreased their early IFN-gamma response and 
      had no effect on the course or outcome of infection. Inhibition of MCP-1 is not 
      beneficial in chlamydial infection because of its pleiotropic effects.
FAU - Darville, T
AU  - Darville T
AD  - Department of Pediatric Infectious Diseases, Arkansas Children's Hospital, 
      University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA. 
      darvilletonil@uams.edu
FAU - Andrews, C W Jr
AU  - Andrews CW Jr
FAU - Sikes, J D
AU  - Sikes JD
FAU - Fraley, P L
AU  - Fraley PL
FAU - Braswell, L
AU  - Braswell L
FAU - Rank, R G
AU  - Rank RG
LA  - eng
GR  - R01 AI043337/AI/NIAID NIH HHS/United States
GR  - AI43337/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokines)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokines/*biosynthesis
MH  - Chlamydia Infections/*immunology
MH  - Chlamydia trachomatis/*immunology
MH  - Female
MH  - Genital Diseases, Female/*immunology
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-10/biosynthesis
MH  - Macrophage Inflammatory Proteins/biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Species Specificity
MH  - Th1 Cells/*immunology
PMC - PMC98830
EDAT- 2001/11/14 10:00
MHDA- 2002/01/05 10:01
PMCR- 2001/12/01
CRDT- 2001/11/14 10:00
PHST- 2001/11/14 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/14 10:00 [entrez]
PHST- 2001/12/01 00:00 [pmc-release]
AID - 0937 [pii]
AID - 10.1128/IAI.69.12.7419-7424.2001 [doi]
PST - ppublish
SO  - Infect Immun. 2001 Dec;69(12):7419-24. doi: 10.1128/IAI.69.12.7419-7424.2001.