PMID- 11705956
OWN - NLM
STAT- MEDLINE
DCOM- 20011212
LR  - 20181113
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 69
IP  - 12
DP  - 2001 Dec
TI  - Interleukin-4 receptor-Stat6 signaling in murine infections with a 
      tissue-dwelling nematode parasite.
PG  - 7743-52
AB  - Interleukin-4 (IL-4) has been shown to be crucial in parasite expulsion in 
      several gastrointestinal nematode infection models. Data from both 
      epidemiological studies with humans and experimental infections in animals imply 
      a critical role for the type II helper response, dominated by IL-4, in host 
      protection. Here we utilized inbred mice on two distinct backgrounds to document 
      the involvement of IL-4 in the clearance of a primary infection of Brugia from 
      the murine host. Our data from infections of IL-4 receptor(-/-) and Stat6(-/-) 
      mice further indicate that IL-4 exerts its effects by activating the Stat6 
      molecule in host target cells, a finding which links clearance requirements of a 
      gastrointestinal tract-dwelling nematode with those of a tissue-dwelling 
      nematode. Additionally, we show that the requirements for IL-4 receptor binding 
      and Stat6 activation extend to accelerated clearance of a secondary infection as 
      well. The data shown here, including analysis of cell populations at the site of 
      infection and infection of immunoglobulin E (IgE)(-/-) mice, lead us to suggest 
      that deficiencies in eosinophil recruitment and isotype switching to IgE 
      production may be at least partially responsible for slower parasite clearance in 
      the absence of IL-4.
FAU - Spencer, L
AU  - Spencer L
AD  - Department of Pathology, University of Connecticut Health Center, Farmington 
      06030-3105, USA.
FAU - Shultz, L
AU  - Shultz L
FAU - Rajan, T V
AU  - Rajan TV
LA  - eng
GR  - AI 39705/AI/NIAID NIH HHS/United States
GR  - AI 42362/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Receptors, Interleukin-4)
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (Stat6 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - *Brugia malayi
MH  - Eosinophils/immunology
MH  - Filariasis/*immunology
MH  - Host-Parasite Interactions
MH  - Immunity, Innate
MH  - Immunoglobulin Class Switching
MH  - Immunoglobulin E/biosynthesis
MH  - Interleukin-4/*pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Mice, SCID
MH  - Peritoneal Cavity/parasitology
MH  - Receptors, Interleukin-4/genetics/*metabolism
MH  - STAT6 Transcription Factor
MH  - Signal Transduction
MH  - Th2 Cells
MH  - Trans-Activators/genetics/*metabolism
PMC - PMC98870
EDAT- 2001/11/14 10:00
MHDA- 2002/01/05 10:01
PMCR- 2001/12/01
CRDT- 2001/11/14 10:00
PHST- 2001/11/14 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/14 10:00 [entrez]
PHST- 2001/12/01 00:00 [pmc-release]
AID - 0633 [pii]
AID - 10.1128/IAI.69.12.7743-7752.2001 [doi]
PST - ppublish
SO  - Infect Immun. 2001 Dec;69(12):7743-52. doi: 10.1128/IAI.69.12.7743-7752.2001.