PMID- 11707161 OWN - NLM STAT- MEDLINE DCOM- 20031010 LR - 20220716 IS - 1523-3812 (Print) IS - 1523-3812 (Linking) VI - 3 IP - 6 DP - 2001 Dec TI - 3,4-methylenedioxymethamphetamine (MDMA): a review. PG - 477-83 AB - This article reviews the history, pharmacology, and adverse events associated with the use of 3,4-methylenendioxymethamphetamine (MDMA), commonly known as Ecstasy. Past research describing the neurotoxic effects of MDMA in animals, current research on the neurotoxic effects of MDMA in humans, and the attendant changes in psychologic functioning will be highlighted in this review. Finally, the limitations of human research on the effects of MDMA and suggestions for future MDMA research will be discussed. FAU - O'Leary, G AU - O'Leary G AD - Harvard Medical School, Alcohol and Drug Abuse Treatment Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. olearyg4@aol.com FAU - Nargiso, J AU - Nargiso J FAU - Weiss, R D AU - Weiss RD LA - eng GR - AA11756/AA/NIAAA NIH HHS/United States GR - DA00326/DA/NIDA NIH HHS/United States GR - DA09400/DA/NIDA NIH HHS/United States GR - DA12849/DA/NIDA NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - United States TA - Curr Psychiatry Rep JT - Current psychiatry reports JID - 100888960 RN - 0 (Hallucinogens) RN - 0 (Receptors, Serotonin) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - Brain/drug effects MH - Depression/chemically induced MH - Hallucinogens/*adverse effects MH - Humans MH - Malignant Hyperthermia/etiology MH - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects MH - Receptors, Serotonin/*drug effects MH - Substance-Related Disorders/*complications RF - 80 EDAT- 2001/11/15 10:00 MHDA- 2003/10/11 05:00 CRDT- 2001/11/15 10:00 PHST- 2001/11/15 10:00 [pubmed] PHST- 2003/10/11 05:00 [medline] PHST- 2001/11/15 10:00 [entrez] AID - 10.1007/s11920-001-0041-y [doi] PST - ppublish SO - Curr Psychiatry Rep. 2001 Dec;3(6):477-83. doi: 10.1007/s11920-001-0041-y.