PMID- 11708601
OWN - NLM
STAT- MEDLINE
DCOM- 20011211
LR  - 20191105
IS  - 1466-2523 (Print)
IS  - 1466-2523 (Linking)
VI  - 1
IP  - 2
DP  - 2000 Dec
TI  - The role of pulmonary intravascular macrophages in porcine reproductive and 
      respiratory syndrome virus infection.
PG  - 95-102
AB  - The objective of this article is to summarize the current state of knowledge of 
      the complex interaction of porcine reproductive and respiratory syndrome virus 
      (PRRSV) and porcine pulmonary intravascular macrophages (PIMs). PIMs play an 
      important role in pulmonary surveillance, and in the past few years we have 
      investigated their role in PRRSV infection. PRRSV antigens and nucleic acids have 
      been demonstrated in PIMs both in vitro and in vivo. Examination of cultured PIMs 
      infected with PRRSV revealed the accumulation of viral particles in the 
      smooth-walled vesicles. PRRSV-infected PIMs in vitro yielded a virus titer 
      similar to pulmonary alveolar macrophages. PRRSV infection induces either 
      apoptosis or cell lysis of PIMs. The in vitro bactericidal activity of 
      PRRSV-infected PIMs is significantly decreased. Phagocytic activity of PIMs, as 
      measured by pulmonary copper clearance, is significantly decreased in 
      PRRSV-infected pigs. This evidence supports the hypothesis that PRRSV-induced 
      damage to PIMs results in increased susceptibility to bacteremic diseases. Recent 
      studies with PRRSV and Streptococcus suis coinfection confirmed that PRRSV 
      predisposes pigs to S. suis infection and bacteremia. These results could explain 
      the increase in bacterial respiratory diseases and septicemias observed in 
      PRRSV-infected pigs.
FAU - Thanawongnuwech, R
AU  - Thanawongnuwech R
AD  - Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn 
      University, Bangkok, Thailand.
FAU - Halbur, P G
AU  - Halbur PG
FAU - Thacker, E L
AU  - Thacker EL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Anim Health Res Rev
JT  - Animal health research reviews
JID - 101083072
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Apoptosis
MH  - Blood Bactericidal Activity
MH  - Cells, Cultured
MH  - Copper/metabolism
MH  - Disease Susceptibility/veterinary
MH  - Macrophages, Alveolar/physiology/*virology
MH  - Phagocytosis
MH  - Porcine Reproductive and Respiratory Syndrome/*physiopathology/virology
MH  - Porcine respiratory and reproductive syndrome virus/*pathogenicity
MH  - Streptococcus suis/pathogenicity
MH  - Swine
MH  - Virus Replication
RF  - 68
EDAT- 2001/11/16 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/16 10:00
PHST- 2001/11/16 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/16 10:00 [entrez]
AID - S1466252300000086 [pii]
AID - 10.1017/s1466252300000086 [doi]
PST - ppublish
SO  - Anim Health Res Rev. 2000 Dec;1(2):95-102. doi: 10.1017/s1466252300000086.